• Publications
  • Influence
Trichothecene 3-O-Acetyltransferase Protects Both the Producing Organism and Transformed Yeast from Related Mycotoxins
TLDR
The results suggested that the introduction of an O-acetyl group at the C-3 position in the biosynthetic pathway works as a resistance mechanism for Fusarium species that produce t-type trichothecenes (trichotheCenes synthesized via the precursor trichotriol). Expand
A diterpene as an endogenous signal for the activation of defense responses to infection with tobacco mosaic virus and wounding in tobacco.
TLDR
Quantitative analysis of endogenous WAF-1 revealed that levels increased rapidly in leaves during a hypersensitive response to Tobacco mosaic virus (TMV) and after wounding, and treatment of leaves with Waf-1 resulted in enhanced resistance to TMV infection. Expand
Nematicidal Alkaloids and Related Compounds Produced by the Fungus Penicillium cf. simplicissimum
TLDR
A new nematicidal alkaloid, peniprequinolone, together with the known alkaloids penigequinolones A and B, and a compound structurally related to cyclopenin also were isolated from the fungus, and their structures were established by spectroscopic analysis. Expand
Gene Encoding the Hydrolase for the Product of the meta-Cleavage Reaction in Testosterone Degradation by Comamonas testosteroni
TLDR
High-pressure liquid chromatography analysis of the culture of TesD-disrupted mutant incubated with testosterone detected five major intermediate compounds, one of which, showing yellow color under neutral conditions, was considered to be the product of the meta-cleavage reaction. Expand
Identification of Genes Involved in Inversion of Stereochemistry of a C-12 Hydroxyl Group in the Catabolism of Cholic Acid by Comamonas testosteroni TA441
TLDR
In the DNA region upstream of the meta-cleavage enzyme gene tesB, two genes required during cholic acid degradation for the inversion of an alpha-oriented hydroxyl group on C-12 were identified. Expand
Fusarium Tri4 encodes a key multifunctional cytochrome P450 monooxygenase for four consecutive oxygenation steps in trichothecene biosynthesis.
TLDR
Results provide unambiguous evidence that FgTri4 encodes a multifunctional CYP for epoxidation at C-12,13, hydroxylation at C -11, and hydroxymation atC-3 in addition to hydroxyation at D-2 of the first committed intermediate trichodiene in the biosynthesis of trichothecenes. Expand
Identification of 9,17-Dioxo-1,2,3,4,10,19-Hexanorandrostan-5-oic Acid, 4-Hydroxy-2-Oxohexanoic Acid, and 2-Hydroxyhexa-2,4-Dienoic Acid and Related Enzymes Involved in Testosterone Degradation in
TLDR
2-Hydroxyhexa-2,4-dienoic acid was converted by a hydratase, TesE, and the product isolated from the reaction solution was identified as 2-hydroxy-4-hex-2-enolactone, indicating the direct product of TesE to be 4-hydroxohexanoic acid. Expand
An ergosterol peroxide, a natural product that selectively enhances the inhibitory effect of linoleic acid on DNA polymerase beta.
TLDR
A natural product from a basidiomycete, Ganoderma lucidum, is found that enhances this effect of LA in a special manner and is identified to be an ergosterol peroxide, 5,8-epidioxy-5alpha,8alpha-ergosta-6,22E-dien -3beta-ol by spectroscopic analyses. Expand
Oocydin A, a chlorinated macrocyclic lactone with potent anti-oomycete activity from Serratia marcescens.
TLDR
Oocydin A had either minimal or no effect against certain Fungi Imperfecti (including several pathogens of humans), two ascomycetes and a basidiomycete and may have potential as an antimycotic in agricultural applications and especially for crop protection. Expand
...
1
2
3
4
5
...