Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies
- G. Gauglitz, H. Korting, T. Pavicic, T. Ruzicka, M. Jeschke
- MedicineMolecular Medicine
The current understanding of the pathophysiology underlying keloid and hypertrophic scar formation is summarized and established treatments and novel therapeutic strategies are discussed.
The pH of the Skin Surface and Its Impact on the Barrier Function
- M. Schmid-Wendtner, H. Korting
- MedicineSkin Pharmacology and Physiology
- 1 November 2006
The ‘acid mantle’ of the stratum corneum seems to be important for both permeability barrier formation and cutaneous antimicrobial defense. However, the origin of the acidic pH, measurable on the…
Hydrolytic enzymes as virulence factors of Candida albicans
- M. Schaller, C. Borelli, H. Korting, B. Hube
- BiologyMycoses (Berlin)
- 1 November 2005
Prevention and control of Candida infections might be achieved by pharmacological or immunological tools specifically modulated to inhibit virulence factors, e.g. the family of Saps.
Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety
- S. Mukherjee, A. Date, V. Patravale, H. Korting, Alexander Roeder, G. Weindl
- MedicineClinical Interventions in Aging
- 1 December 2006
N nanoparticles have shown a good potential in improving the stability, tolerability and efficacy of retinoid like tretinoin and retinol, however, more elaborate clinical studies are required to confirm their advantage in the delivery of topical retinoids.
Lipid nanoparticles for improved topical application of drugs for skin diseases.
- M. Schäfer-Korting, W. Mehnert, H. Korting
- BiologyAdvanced Drug Delivery Reviews
- 10 July 2007
Candida albicans Hyphal Formation and the Expression of the Efg1-Regulated Proteinases Sap4 to Sap6 Are Required for the Invasion of Parenchymal Organs
- A. Felk, M. Kretschmar, B. Hube
- Biology, MedicineInfection and Immunity
- 1 July 2002
It can be concluded that the reduced virulence of hypha-deficient mutants is not only due to the inability to form hyphae but also due to modified expression of the SAP genes normally associated with the hyphal morphology, particularly that encoded by SAP6.
Differential expression of secreted aspartyl proteinases in a model of human oral candidosis and in patient samples from the oral cavity
- M. Schaller, W. Schäfer, H. Korting, B. Hube
- Biology, MedicineMolecular Microbiology
- 1 July 1998
The results suggest that the pathogenesis of experimental and clinical oral candidosis is associated with the differential and temporal regulation of SAP gene expression.
Infection of human oral epithelia with Candida species induces cytokine expression correlated to the degree of virulence.
- M. Schaller, R. Mailhammer, G. Grassl, C. Sander, B. Hube, H. Korting
- Biology, MedicineJournal of Investigative Dermatology
- 1 April 2002
A correlation between the virulence potential of pathogenic fungi and the secretion of epithelial cytokines and chemokines, which may initiate in vivo a protective T helper 1 immunologic response and contribute to the recruitment of activated leukocytes and lymphocytes to the site of mucosal infection is shown.
Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling.
- G. Weindl, J. Naglik, M. Schaller
- BiologyJournal of Clinical Investigation
- 3 December 2007
It is demonstrated that human epithelial TLR4 directly protected the oral mucosa from fungal infection via a process mediated by polymorphonuclear leukocytes (PMNs), the first description of such a PMN-dependent,TLR4-mediated protective mechanism at epithelial surfaces.
Toll-like receptors as key mediators in innate antifungal immunity.
- Alexander Roeder, C. Kirschning, R. Rupec, M. Schaller, G. Weindl, H. Korting
- BiologyMedical Mycology
- 1 December 2004
Recent evidence further suggests that TLRs cooperate with other immune receptors involved in fungal recognition and that the selective induction of adaptor proteins finally leads to distinct signalling events upon fungal challenge.