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Streptomyces associated with a marine sponge Haliclona sp.; biosynthetic genes for secondary metabolites and products.
This is the first comprehensive study detailing the isolation of actinobacteria from a marine sponge and novel secondary metabolites from these strains, and JBIR-34 and -35 were particularly interesting because of their unique chemical skeleton.
DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters
DoBISCUIT (Database of BIoSynthesis clusters CUrated and InTegrated), a literature-based, manually curated database of gene clusters for secondary metabolite biosynthesis, provides standardized gene/module/domain descriptions related to the gene clusters.
Brasilicardin A, a new terpenoid antibiotic from pathogenic Nocardia brasiliensis: fermentation, isolation and biological activity.
A novel tricyclic diterpenoid antibiotic was isolated from the culture broth of Nocardia brasiliensis IFM 0406 and the results of in vitro toxicity testing of brasilicardin A against various human cell lines were compared with those of CyA.
Novel siderophore, JBIR-16, isolated from Nocardia tenerifensis NBRC 101015
In the course of the screening program for biologically active compounds of microbial origin, a novel heterobactin12 analog, JBIR-16 (1), containing hydroxamate and catecholate, was isolated from the culture broth of Nocardia tenerifensis NBRC 101015, revealing the characteristic absorptions of amide carbonyl and amide N–H groups.
Brasilinolide A, a new macrolide antibiotic produced by Nocardia brasiliensis: producing strain, isolation and biological activity.
A new 32-membered macrolide antibiotic, brasilinolide A was isolated from the fermentation broth of Nocardia sp. IFM 0406. The producer was identified as Nocardia brasiliensis. The antibiotic was
Different Rifampicin Inactivation Mechanisms in Nocardia and Related Taxa
Mycolic acid‐containing bacteria inactivate rifampicin in a variety of ways such as glucosylation, ribosylation, phosphorylation and decolorization. These inactivations were found to be a
Physicochemical characters of a tyrosinase inhibitor produced by Streptomyces roseolilacinus NBRC 12815.
It is suggested that the chlorine and the hydration water are very important in the exertion of anti-tyrosinase activity by 12815A, and the active compounds are SF 2583A and B.
Nocarasins A−C and Brasiliquinone D, New Metabolites from the Actinomycete Nocardia brasiliensis
Four new metabolites, nocarasins A−C (1−3) and brasiliquinone D (4), have been isolated from the actinomycete Nocardia brasiliensis IFM 0667, and the structures were elucidated on the basis of