Streptomyces associated with a marine sponge Haliclona sp.; biosynthetic genes for secondary metabolites and products.
This is the first comprehensive study detailing the isolation of actinobacteria from a marine sponge and novel secondary metabolites from these strains, and JBIR-34 and -35 were particularly interesting because of their unique chemical skeleton.
New Sesquiterpenes, JBIR-27 and -28, Isolated from a Tunicate-Derived Fungus, Penicillium sp. SS080624SCf1.
DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters
DoBISCUIT (Database of BIoSynthesis clusters CUrated and InTegrated), a literature-based, manually curated database of gene clusters for secondary metabolite biosynthesis, provides standardized gene/module/domain descriptions related to the gene clusters.
Brasilicardin A, a new terpenoid antibiotic from pathogenic Nocardia brasiliensis: fermentation, isolation and biological activity.
A novel tricyclic diterpenoid antibiotic was isolated from the culture broth of Nocardia brasiliensis IFM 0406 and the results of in vitro toxicity testing of brasilicardin A against various human cell lines were compared with those of CyA.
Novel siderophore, JBIR-16, isolated from Nocardia tenerifensis NBRC 101015
- Akira Mukai, H. Komaki, M. Takagi, K. Shin‐ya
- ChemistryJournal of antibiotics (Tokyo. )
- 21 August 2009
In the course of the screening program for biologically active compounds of microbial origin, a novel heterobactin12 analog, JBIR-16 (1), containing hydroxamate and catecholate, was isolated from the culture broth of Nocardia tenerifensis NBRC 101015, revealing the characteristic absorptions of amide carbonyl and amide N–H groups.
Brasilicardin A. A Novel Tricyclic Metabolite with Potent Immunosuppressive Activity from Actinomycete Nocardia brasiliensis
Isolation and structure determination of a new antibacterial peptide pentaminomycin C from Streptomyces cacaoi subsp. cacaoi
- I. Kaweewan, H. Hemmi, H. Komaki, S. Kodani
- Chemistry, BiologyJournal of antibiotics (Tokyo. )
- 10 January 2020
A new antibacterial peptide named pentaminomycin C was isolated from an extract of Streptomyces cacaoi NBRC 12748T along with a known peptide BE-18257A, and exhibited antibacterial activities against Gram-positive bacteria including Micrococcus luteus, Bacillus subtilis, and Staphylococcus aureus.
Discovery of a pimaricin analog JBIR-13, from Streptomyces bicolor NBRC 12746 as predicted by sequence analysis of type I polyketide synthase gene
- H. Komaki, M. Izumikawa, K. Shin‐ya
- Biology, ChemistryApplied Microbiology and Biotechnology
- 21 January 2009
It is strongly suggested that a careful analysis of PKS-I genes can provide valuable information in the search of novel bioactive compounds within a class predicted from phylogenetic analysis.
Brasilinolide A, a new macrolide antibiotic produced by Nocardia brasiliensis: producing strain, isolation and biological activity.
A new 32-membered macrolide antibiotic, brasilinolide A was isolated from the fermentation broth of Nocardia sp. IFM 0406. The producer was identified as Nocardia brasiliensis. The antibiotic was…
Different Rifampicin Inactivation Mechanisms in Nocardia and Related Taxa
Mycolic acid‐containing bacteria inactivate rifampicin in a variety of ways such as glucosylation, ribosylation, phosphorylation and decolorization. These inactivations were found to be a…