Streptomyces associated with a marine sponge Haliclona sp.; biosynthetic genes for secondary metabolites and products.
- S. Khan, H. Komaki, K. Shin‐ya
- Biology, EngineeringEnvironmental Microbiology
- 1 February 2011
This is the first comprehensive study detailing the isolation of actinobacteria from a marine sponge and novel secondary metabolites from these strains, and JBIR-34 and -35 were particularly interesting because of their unique chemical skeleton.
New Sesquiterpenes, JBIR-27 and -28, Isolated from a Tunicate-Derived Fungus, Penicillium sp. SS080624SCf1.
- K. Motohashi, J. Hashimoto, K. Shin‐ya
- Chemistry
- 29 September 2009
DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters
- Natsuko Ichikawa, Machi Sasagawa, N. Fujita
- BiologyNucleic Acids Res.
- 25 November 2012
DoBISCUIT (Database of BIoSynthesis clusters CUrated and InTegrated), a literature-based, manually curated database of gene clusters for secondary metabolite biosynthesis, provides standardized gene/module/domain descriptions related to the gene clusters.
Brasilicardin A, a new terpenoid antibiotic from pathogenic Nocardia brasiliensis: fermentation, isolation and biological activity.
A novel tricyclic diterpenoid antibiotic was isolated from the culture broth of Nocardia brasiliensis IFM 0406 and the results of in vitro toxicity testing of brasilicardin A against various human cell lines were compared with those of CyA.
Novel siderophore, JBIR-16, isolated from Nocardia tenerifensis NBRC 101015
- Akira Mukai, H. Komaki, M. Takagi, K. Shin‐ya
- ChemistryJournal of antibiotics (Tokyo. )
- 21 August 2009
In the course of the screening program for biologically active compounds of microbial origin, a novel heterobactin12 analog, JBIR-16 (1), containing hydroxamate and catecholate, was isolated from the culture broth of Nocardia tenerifensis NBRC 101015, revealing the characteristic absorptions of amide carbonyl and amide N–H groups.
Brasilicardin A. A Novel Tricyclic Metabolite with Potent Immunosuppressive Activity from Actinomycete Nocardia brasiliensis
- H. Shigemori, H. Komaki, J. Kobayashi
- Biology
- 9 February 1999
Isolation and structure determination of a new antibacterial peptide pentaminomycin C from Streptomyces cacaoi subsp. cacaoi
- I. Kaweewan, H. Hemmi, H. Komaki, S. Kodani
- Chemistry, BiologyJournal of antibiotics (Tokyo. )
- 10 January 2020
A new antibacterial peptide named pentaminomycin C was isolated from an extract of Streptomyces cacaoi NBRC 12748T along with a known peptide BE-18257A, and exhibited antibacterial activities against Gram-positive bacteria including Micrococcus luteus, Bacillus subtilis, and Staphylococcus aureus.
Discovery of a pimaricin analog JBIR-13, from Streptomyces bicolor NBRC 12746 as predicted by sequence analysis of type I polyketide synthase gene
- H. Komaki, M. Izumikawa, K. Shin‐ya
- Biology, ChemistryApplied Microbiology and Biotechnology
- 21 January 2009
It is strongly suggested that a careful analysis of PKS-I genes can provide valuable information in the search of novel bioactive compounds within a class predicted from phylogenetic analysis.
Brasilinolide A, a new macrolide antibiotic produced by Nocardia brasiliensis: producing strain, isolation and biological activity.
- Y. Tanaka, H. Komaki, J. Kobayashi
- BiologyJournal of antibiotics (Tokyo. )
- 25 December 1997
A new 32-membered macrolide antibiotic, brasilinolide A was isolated from the fermentation broth of Nocardia sp. IFM 0406. The producer was identified as Nocardia brasiliensis. The antibiotic was…
Different Rifampicin Inactivation Mechanisms in Nocardia and Related Taxa
- Yasushi Tanaka, K. Yazawa, S. Iwasaki
- BiologyMicrobiology and immunology
- 1 January 1996
Mycolic acid‐containing bacteria inactivate rifampicin in a variety of ways such as glucosylation, ribosylation, phosphorylation and decolorization. These inactivations were found to be a…
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