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Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients.
Fibroblast growth factor 23 (FGF23) exerts its effect by binding to its cognate FGF receptor 1 (FGFR1) in the presence of its co-receptor Klotho. Parathyroid glands express both FGFR1 and Klotho, and… Expand
Clinical practice guideline for the management of chronic kidney disease-mineral and bone disorder.
FGF23-parathyroid interaction: implications in chronic kidney disease.
Over the past few years there have been considerable advances in our understanding of the physiological regulation of mineral homeostasis. One of the most important breakthroughs is the… Expand
Diseases of the parathyroid gland in chronic kidney disease
During the past few years, remarkable advances have been made in the understanding and the management of parathyroid diseases in patients with chronic kidney disease (CKD). One of the important… Expand
Cost-effectiveness of alendronate for the treatment of osteopenic postmenopausal women in Japan.
- Kensuke Moriwaki, H. Komaba, +6 authors H. Takahashi
- Journal of bone and mineral research : the…
- 1 February 2013
Many postmenopausal women have osteopenia, a condition characterized by loss of bone mineral density (BMD) that is not as severe as in osteoporosis. The objective of this study was to estimate the… Expand
PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer.
Cachexia is a wasting syndrome associated with elevated basal energy expenditure and loss of adipose and muscle tissues. It accompanies many chronic diseases including renal failure and cancer and is… Expand
Parathyroidectomy and survival among Japanese hemodialysis patients with secondary hyperparathyroidism.
- H. Komaba, Masatomo Taniguchi, A. Wada, K. Iseki, Y. Tsubakihara, M. Fukagawa
- Kidney international
- 1 August 2015
Parathyroidectomy (PTx) drastically improves biochemical parameters and clinical symptoms related to severe secondary hyperparathyroidism (SHPT) but the effect of PTx on survival has not been… Expand
Cost-effectiveness of cinacalcet hydrochloride for hemodialysis patients with severe secondary hyperparathyroidism in Japan.
- H. Komaba, K. Moriwaki, +5 authors M. Fukagawa
- American journal of kidney diseases : the…
- 1 August 2012
BACKGROUND Cinacalcet effectively reduces elevated levels of parathyroid hormone (PTH) in patients with secondary hyperparathyroidism (SHPT), even those with severe disease for whom parathyroidectomy… Expand
Optimizing the cost-effectiveness of treatment for chronic kidney disease-mineral and bone disorder
- Shunsuke Goto, H. Komaba, M. Fukagawa, S. Nishi
- Kidney international supplements
- 27 November 2013
Chronic kidney disease-mineral and bone disorder (CKD-MBD) is an important risk factor in patients with CKD, and some medications for treating CKD-MBD have been recently marketed. Because assessment… Expand
Treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD).
Disturbances in mineral and bone metabolism play a critical role in the pathogenesis of cardiovascular complications in patients with chronic kidney disease (CKD). The term "renal osteodystrophy" has… Expand