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Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome
Dorsal-ventral limb patterning in vertebrates is thought to be controlled by the LIM-homeodomain protein Lmx1b which is expressed in a spatially and temporally restricted manner along theExpand
Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning.
Dmrt2 is expressed in the dermomyotome of developing vertebrate somites. To determine the role of Dmrt2 during mouse embryonic development, we generated a null mutation of Dmrt2 via homologousExpand
Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea.
In cochlear development, the Notch signaling pathway is required for both the early prosensory phase and a later lateral inhibition phase. While it is known that Hes genes are important downstreamExpand
Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system.
Notch signaling is required for multiple aspects of cardiovascular development, including arterial-venous differentiation, septation and cushion formation. Despite recognition of the importance ofExpand
Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2
The establishment of chamber specificity is an essential requirement for cardiac morphogenesis and function. Hesr1 (Hey1) and Hesr2 (Hey2) are specifically expressed in the atrium and ventricle,Expand
Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split.
In this report we describe the initial characterization of murine, human, and Drosophila hesr-1 (for hairy and enhancer of split related-1) a novel evolutionary conserved family of hairy/enhancer ofExpand
The Drosophila fork head factor directly controls larval salivary gland-specific expression of the glue protein gene Sgs3.
The Drosophila Fork head protein participates in salivary gland formation, since salivary glands are missing in fork head embryos. Here we show that the fork head encoded protein binds to an upstreamExpand
Expression pattern analysis of SGF‐3/POU‐M1 in relation to sericin‐1 gene expression in the silk gland
Embryonic and larval expression patterns of the sericin‐1 gene and its presumed transcription factor, SGF‐3/POU‐M1, in the silk gland were analyzed by in situ hybridization and immunohistochemistry.Expand
Developmental expression of the Bombyx Antennapedia homologue and homeotic changes in the Nc mutant
Background: Abundant availability of homeotic mutants in Bombyx mori provides us with clues to study the body plan of the silkworm. Previous studies indicated that the ECa/ECa and EN/EN embryos,Expand
Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under the control of Notch signaling
During vertebrate embryogenesis, the formation of reiterated structures along the body axis is dependent upon the generation of the somite by segmentation of the presomitic mesoderm (PSM). NotchExpand