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Multilineage differentiation of Cbfa1-deficient calvarial cells in vitro.
TLDR
Calvaria-derived cells of Cbfa1-deficient mice were enriched with immature mesenchymal cells, which can differentiate into adipocytes and chondrocytes, and it was suggested that Cffa1 plays an essential role in determining the lineage of multipotential mesenchyal precursor cells.
Enhancement of antigen-presenting cell surface molecules involved in cognate interactions by immunostimulatory DNA sequences.
TLDR
It is shown that ISS-enriched DNA up-regulates a distinct profile of cell surface molecules on macrophages and B cells in vitro and in vivo and contributes to the potent immunostimulatory effects of ISS-containing DNA on innate and adaptive immunity.
Genetic characterization of the multipotent dedifferentiated state of pigmented epithelial cells in vitro.
TLDR
Results indicated that lens transdifferentiation from PECs proceeds through a multipotent (or at least bipotent) intermediate cell state in which the c-myc gene is activated, but neither PEC- nor lens-specific genes are expressed.
Scabronine G-methylester enhances secretion of neurotrophic factors mediated by an activation of protein kinase C-zeta.
TLDR
The results suggest that scabronine G-ME potentially enhances the secretion of neurotrophic factors from 1321N1 cells mediated via the activation of PKC-zeta.
The role of nuclear factor-kappa B in bacterial translocation in cholestatic rats
TLDR
Xanthinoxidase derived radical species are involved in bacterial translocation in cholestatic rats and may be activated by XO derived ROS, which disrupts the tight junctions leading to BT from the intestinal lumen to the MLNs and circulation.
Immunostimulatory DNA pre-priming: a novel approach for prolonged Th1-biased immunity.
TLDR
The results demonstrate that ISS prepriming can induce immune responses that are significantly stronger than with ISS/antigen covaccination, and offers an alternative approach to the traditional use of adjuvants and expands the potential clinical applications for ISS.
Involvement of Phosphatidylcholine‐Specific Phospholipase C in Thromboxane A2‐Induced Activation of Mitogen‐Activated Protein Kinase in Astrocytoma Cells
TLDR
Results suggest that phosphatidylcholine‐specific phospholipase C and protein kinase C, but not phosph atidylinositol‐specificospholipases C, are involved in TXA2 receptor‐mediated MAPK activation in 1321N1 human astrocytoma cells.
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