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Multilineage differentiation of Cbfa1-deficient calvarial cells in vitro.
- H. Kobayashi, Y. Gao, C. Ueta, A. Yamaguchi, T. Komori
- Biology, MedicineBiochemical and biophysical research…
- 5 July 2000
Calvaria-derived cells of Cbfa1-deficient mice were enriched with immature mesenchymal cells, which can differentiate into adipocytes and chondrocytes, and it was suggested that Cffa1 plays an essential role in determining the lineage of multipotential mesenchyal precursor cells.
Enhancement of antigen-presenting cell surface molecules involved in cognate interactions by immunostimulatory DNA sequences.
- E. Martín-Orozco, H. Kobayashi, J. V. Van Uden, M. Nguyen, R. Kornbluth, E. Raz
- Biology, MedicineInternational immunology
- 1 July 1999
It is shown that ISS-enriched DNA up-regulates a distinct profile of cell surface molecules on macrophages and B cells in vitro and in vivo and contributes to the potent immunostimulatory effects of ISS-containing DNA on innate and adaptive immunity.
Genetic characterization of the multipotent dedifferentiated state of pigmented epithelial cells in vitro.
Results indicated that lens transdifferentiation from PECs proceeds through a multipotent (or at least bipotent) intermediate cell state in which the c-myc gene is activated, but neither PEC- nor lens-specific genes are expressed.
Stimulation of neurotrophic factor secretion from 1321N1 human astrocytoma cells by novel diterpenoids, scabronines A and G.
Scabronine G-methylester enhances secretion of neurotrophic factors mediated by an activation of protein kinase C-zeta.
- Y. Obara, H. Kobayashi, T. Ohta, Y. Ohizumi, N. Nakahata
- Biology, ChemistryMolecular pharmacology
- 1 May 2001
The results suggest that scabronine G-ME potentially enhances the secretion of neurotrophic factors from 1321N1 cells mediated via the activation of PKC-zeta.
Expression of gene coding for a melanosomal matrix protein transcriptionally regulated in the transdifferentiation of chick embryo pigmented epithelial cells.
The role of nuclear factor-kappa B in bacterial translocation in cholestatic rats
Xanthinoxidase derived radical species are involved in bacterial translocation in cholestatic rats and may be activated by XO derived ROS, which disrupts the tight junctions leading to BT from the intestinal lumen to the MLNs and circulation.
Immunostimulatory DNA pre-priming: a novel approach for prolonged Th1-biased immunity.
The results demonstrate that ISS prepriming can induce immune responses that are significantly stronger than with ISS/antigen covaccination, and offers an alternative approach to the traditional use of adjuvants and expands the potential clinical applications for ISS.
Nerve growth factor and neurotrophin-3 promote chemotaxis of mouse macrophages in vitro
Involvement of Phosphatidylcholine‐Specific Phospholipase C in Thromboxane A2‐Induced Activation of Mitogen‐Activated Protein Kinase in Astrocytoma Cells
- H. Kobayashi, S. Honma, N. Nakahata, Y. Ohizumi
- Biology, ChemistryJournal of neurochemistry
- 1 May 2000
Results suggest that phosphatidylcholine‐specific phospholipase C and protein kinase C, but not phosph atidylinositol‐specificospholipases C, are involved in TXA2 receptor‐mediated MAPK activation in 1321N1 human astrocytoma cells.