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Subcellular targeting strategies for drug design and delivery
The fundamentals of membrane trafficking and subcellular organization are explored, as well as strategies used by pathogens to appropriate these mechanisms and the implications for drug design and delivery are explored.
Myosin II-mediated cell shape changes and cell intercalation contribute to primitive streak formation
Primitive streak formation in the chick embryo involves large-scale highly coordinated flows of more than 100,000 cells in the epiblast and use of class specific myosin inhibitors and gene-specific knockdown shows that apical contraction and intercalation areMyosin II dependent and also reveal critical roles for myOSin I and myos in V family members in the assembly of junctional myosIn II cables.
DAF-12 Regulates a Connected Network of Genes to Ensure Robust Developmental Decisions
Together these data are consistent with daf-12 acting to ensure developmental robustness by committing the animal to adult or dauer developmental programs despite variable internal or external conditions.
Efficient Inhibition of the Alzheimer's Disease β-Secretase by Membrane Targeting
This work synthesized a membrane-anchored version of a β-secretase transition-state inhibitor by linking it to a sterol moiety and targeted the inhibitor to active β- secretase found in endosomes and also reduced the dimensionality of the inhibitor, increasing its local membrane concentration.
Sterol-Derived Hormone(s) Controls Entry into Diapause in Caenorhabditis elegans by Consecutive Activation of DAF-12 and DAF-16
It is found that replacing cholesterol with its methylated metabolite lophenol induced worms to form dauer larvae in the presence of food and low population density and determined the role of sterols during dauer larva formation and longevity.
Methylation of the sterol nucleus by STRM-1 regulates dauer larva formation in Caenorhabditis elegans.
A methyltransferase, STRM-1, is identified that modulates DA levels and thus dauer formation in Caenorhabditis elegans and could be a target for therapeutic strategies against parasitic nematode infections.
The mechanism of pentabromopseudilin inhibition of myosin motor activity
PBP-induced reductions in the rate constants for ATP binding, ATP hydrolysis and ADP dissociation extend the time required per myosin ATPase cycle in the absence and presence of actin.
Myosin 1b functions as an effector of EphB signaling to control cell repulsion
Myosin 1b functions as an effector of EphB2/ephrinB signaling and controls cell morphology and cell repulsion.
Myosin 1E localizes to actin polymerization sites in lamellipodia, affecting actin dynamics and adhesion formation
It is suggested that, by moving to actin polymerization sites and early adhesion sites in active lamellipodia, Myosin 1E might play important roles in transporting not only important polymerizing proteins but also proteins involved in adhesion stabilization.
Iron catalysis in organic synthesis.