H. Klenk

Publications504
h-index101
Citations38,310
Highly Influential Citations1,453
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Identification of a novel coronavirus in patients with severe acute respiratory syndrome.
TLDR
The novel coronavirus might have a role in causing SARS and was detected in a variety of clinical specimens from patients with SARS but not in controls. Expand
The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host.
TLDR
Specific mutations in SC35M polymerase considerably increase its activity in mammalian cells, correlating with high virulence in mice, demonstrating convergent evolution in nature and may be a prerequisite for adaptation to a new host paving the way for new pandemic viruses. Expand
New low-viscosity overlay medium for viral plaque assays
TLDR
Plaque assay under Avicel-containing overlay media is easier, faster and more sensitive than assays under agar- and methylcellulose overlays and seems particularly suitable for high-throughput virus titrations, serological studies and experiments on viral drug sensitivity. Expand
The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P
TLDR
It is shown here that GP-C is cleaved in the endoplasmic reticulum by the cellular subtilase SKI-1/S1P, an enzyme that has so far been observed to be involved in cholesterol metabolism. Expand
Human and avian influenza viruses target different cell types in cultures of human airway epithelium.
TLDR
It is demonstrated that influenza viruses enter the airway epithelium through specific target cells and that there were striking differences in this respect between human and avian viruses. Expand
Processing of the Ebola virus glycoprotein by the proprotein convertase furin.
TLDR
It is considered that proteolytic processing of GP may be an important determinant for the pathogenicity of Ebola virus. Expand
Comparison of the Transcription and Replication Strategies of Marburg Virus and Ebola Virus by Using Artificial Replication Systems
TLDR
To compare the replication and transcription strategies of both viruses, an artificial replication system based on the vaccinia virus T7 expression system was established for EBOV and it was observed that neither MBGV nor E BOV were able to replicate the heterologous minigenomes. Expand
Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses
TLDR
The data suggest that these replication-competent vaccines against EBOV and MARV based on attenuated recombinant vesicular stomatitis virus vectors are safe and highly efficacious in a relevant animal model. Expand
Proteolytic cleavage of the viral glycoproteins and its significance for the virulence of Newcastle disease virus.
Abstract In search of a molecular basis underlying the variations in virulence observed with different strains of Newcastle disease virus, a comparative study has been carried out on the biosynthesis… Expand
Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin‐like endoprotease.
TLDR
Peptidyl chloroalkylketones containing the R‐X‐K/R‐R motif specifically bind to the catalytic site of furin and are therefore potent inhibitors of hemagglutinin cleavage and fusion activity. Expand
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