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Identification of a novel coronavirus in patients with severe acute respiratory syndrome.
TLDR
The novel coronavirus might have a role in causing SARS and was detected in a variety of clinical specimens from patients with SARS but not in controls.
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The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host.
TLDR
Specific mutations in SC35M polymerase considerably increase its activity in mammalian cells, correlating with high virulence in mice, demonstrating convergent evolution in nature and may be a prerequisite for adaptation to a new host paving the way for new pandemic viruses.
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New low-viscosity overlay medium for viral plaque assays
TLDR
Plaque assay under Avicel-containing overlay media is easier, faster and more sensitive than assays under agar- and methylcellulose overlays and seems particularly suitable for high-throughput virus titrations, serological studies and experiments on viral drug sensitivity.
View on Springer
Comparison of the Transcription and Replication Strategies of Marburg Virus and Ebola Virus by Using Artificial Replication Systems
TLDR
To compare the replication and transcription strategies of both viruses, an artificial replication system based on the vaccinia virus T7 expression system was established for EBOV and it was observed that neither MBGV nor E BOV were able to replicate the heterologous minigenomes.
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The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P
TLDR
It is shown here that GP-C is cleaved in the endoplasmic reticulum by the cellular subtilase SKI-1/S1P, an enzyme that has so far been observed to be involved in cholesterol metabolism.
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Human and avian influenza viruses target different cell types in cultures of human airway epithelium.
TLDR
It is demonstrated that influenza viruses enter the airway epithelium through specific target cells and that there were striking differences in this respect between human and avian viruses.
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SARS — beginning to understand a new virus
TLDR
The genomics of the Sars coronavirus (SARS-CoV), its phylogeny, antigenic structure, immune response and potential therapeutic interventions should the SARS epidemic flare up again are reviewed.
View on Nature
Processing of the Ebola virus glycoprotein by the proprotein convertase furin.
TLDR
It is considered that proteolytic processing of GP may be an important determinant for the pathogenicity of Ebola virus.
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TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells
TLDR
It is shown that S can be cleaved by the proprotein convertase furin at the S1/S2 site and the transmembrane serine protease 2 (TMPRSS2) at theS2′ site, and this approach has considerable therapeutic potential for treatment of COVID-19.
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Proteolytic Activation of Influenza Viruses by Serine Proteases TMPRSS2 and HAT from Human Airway Epithelium
TLDR
The cloned two human type II transmembrane serine proteases with known airway localization, TMPRSS2 and HAT, are suggested to be candidates for proteolytic activation of influenza viruses in vivo.
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