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Memory trace of motor learning shifts transsynaptically from cerebellar cortex to nuclei for consolidation
Adaptation of ocular reflexes is a prototype of motor learning. While the cerebellum is acknowledged as the critical site for motor learning, the functional differences between the cerebellar cortexExpand
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Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function.
Animals vary in their sensitivity to ethanol, a trait at least partly determined by genetic factors. In order to identify possible responsible genes, mice lacking Fyn, a non-receptor type tyrosineExpand
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Dynamic characteristics and adaptability of mouse vestibulo-ocular and optokinetic response eye movements and the role of the flocculo-olivary system revealed by chemical lesions.
The dynamic characteristics of reflex eye movements were measured in two strains of chronically prepared mice by using an infrared television camera system. The horizontal vestibulo-ocular reflexExpand
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Role of primate cerebellar hemisphere in voluntary eye movement control revealed by lesion effects.
The anatomical connection between the frontal eye field and the cerebellar hemispheric lobule VII (H-VII) suggests a potential role of the hemisphere in voluntary eye movement control. To reveal theExpand
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Effects of reversible shutdown of the monkey flocculus on the retention of adaptation of the horizontal vestibulo-ocular reflex
There are two different proposals regarding the role of the cerebellar flocculus in the adaptation of the vestibulo-ocular reflex: that the flocculus is the site for both the induction and retentionExpand
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Abnormal synaptic transmission in the olfactory bulb of Fyn-kinase-deficient mice.
We studied synaptic transmission in the granule cells in the olfactory bulb of the homozygous Fyn (a nonreceptor type tyrosine kinase)-deficient (fynz/fynz) and heterozygous Fyn-deficient (+/fynz)Expand
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Effects of reversible pharmacological shutdown of cerebellar flocculus on the memory of long-term horizontal vestibulo-ocular reflex adaptation in monkeys
The adaptation of the horizontal vestibulo-ocular reflex (HVOR) provides an experimental model for motor learning. Two studies, using cats and mice, respectively, have recently suggestedExpand
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Difference of climbing fiber input sources between the primate oculomotor-related cerebellar vermis and hemisphere revealed by a retrograde tracing study
The cerebellar flocculus-paraflocculus complex, vermal lobule VII (V-7) and hemispheric lobule VII (H-7) are involved in learning-dependent smooth pursuit eye movement control. To locate the sourcesExpand
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Adaptive modifications of post-saccadic smooth pursuit eye movements and their interaction with saccades and the vestibulo-ocular reflex in the primate
Adaptation of the horizontal smooth pursuit eye movement was examined using step-ramp moving target paradigms in chronically prepared Macaca fuscata. Monkeys were trained to pursue a small targetExpand
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[Role of the cerebellum in the acquisition and consolidation of motor memory].
Most of our motor skills are acquired through learning. Although the cerebellum is established as the critical site for motor learning, the precise mechanism underlying acquisition and consolidationExpand
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