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Acetaldehyde, a metabolite of ethanol, activates the hypothalamic-pituitary-adrenal axis in the rat.
Results suggest that acetaldehyde, induced by blocking ethanol metabolism, is able to activate the HPA axis operating through a central mechanism. Expand
EFFECTS OF WHOLE DELETION OF CYP2A6 ON NICOTINE METABOLISM IN HUMANS
The effects of CYP2A6 genotypes on nicotine metabolism, focused from nicotine to cotinine and its additional 3′-hydroxylating resulted in trans-3′-Hydroxycotinine formation, are investigated. Expand
A perspective in epidemiology of suicide in Japan.
Male suicide rates have gradually increased with the four temporal steep risings during the 20th century, while those of females have generally reached the stabilisation with no fluctuations, and suicide rate was the highest in the Akita and Iwate prefectures. Expand
An autopsy case of multiple psychotropic drug poisoning.
The cause of death was due to the interaction of multiple psychotropic drugs, including etizolam, phenobarbital, promethazine and chlorpromazine. Expand
Effects of acetaldehyde on c-fos mRNA induction in the paraventricular nucleus following ethanol administration.
- H. Kinoshita, D. Jessop, +4 authors M. Harbuz
- Chemistry, Medicine
- Alcohol and alcoholism
- 1 September 2002
The data suggest that acetaldehyde accumulation in blood has an important stimulatory effect on c-fos expression in the PVN at low ethanol concentrations and appears to be an either/or response: not activated in response to low dose ethanol, but maximally to high dose ethanol. Expand
Acute ethanol decreases NPY mRNA but not POMC mRNA in the arcuate nucleus
It is suggested that ethanol suppresses NPY gene expression in ARC and may play a role in ethanol-induced changes in neuronal function. Expand
Relationship between Alcoholism and CYP2E1 C/D Polymorphism
There was a significant difference in the CYP2E1 C gene frequency between alcohol dependents and controls, suggesting that the C gene may be related to the risk of developing alcoholism in Japanese, whereas the frequency of the D gene was higher among controls than alcoholics. Expand
Blood carbofuran concentrations in suicidal ingestion cases.
Four fatal cases due to ingestion of carbofuran, a carbamate insecticide, are described and concentrations in the blood ranged from 0.32 to 11.6 microg/ml. Expand
Detection of two metabolites of diquat in urine and serum of poisoned patients after ingestion of a combined herbicide of paraquat and diquat
Results indicate that diquat is metabolized to diqu at-monopyridone and diquAt-dipyrid one and also that the metabolism of diquats metabolism is easier than that of paraquat in humans. Expand
Different blood acetaldehyde concentration following ethanol administration in a newly developed high alcohol preference and low alcohol preference rat model system.
It is suggested that the ALDH1 polymorphism is associated with alcohol preference in HAP/LAP lines through some other unidentified mechanism and there may be little direct relationship between acetaldehyde accumulation and alcohol preference. Expand