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The metabolic disposition of 14C-ciramadol in humans.
Twelve subjects received single 15 mg oral doses of 14C-ciramadol. Excretion of the dose occurred almost entirely by the renal route (93.5 +/- 11.7 (S.D.)% of the dose), and only 0.7 +/- 0.6% of theExpand
ABSORPTION, METABOLISM, AND EXCRETION OF OXAZEPAM AND ITS SUCCINATE HALF-ESTER.
C 14 -Oxazepam was administered orally to dogs, rats, and pigs. Radioassay of blood, various tissues, and excreta indicated that the drug was well absorbed. A single dose was largely eliminatedExpand
Species-related differences in the stereoselective glucuronidation of oxazepam.
The concentrations of (R)-(-)- and (S)-(+)-oxazepam glucuronides in plasma and urine of several species have been measured. The relative amounts of these diastereoisomers vary among species. Thus, inExpand
Excretion and stereoselective biotransformations of dl-, d- and l-norgestrel in women.
Excretion data and urinary metabolite patterns of di-, d-, and l-norgestrel were obtained from women who received a single, oral 1.5-mg dose of 14C-labeled racemic norgestrel (Ng) or one of itsExpand
Urinary metabolites of DL-norgestrel in women.
In order to isolate characterize and identify the excretion product of dl-norgestrel in humans 4 female volunteers from 23-34 years were given a single capsule containing 1.5 mg 14C-dl-norgestrel.Expand
The presence of dl-, d- and l-norgestrel and their metabolites in the plasma of women.
Abstract Women of childbearing potential were given single 1.5 mg oral doses of 14C- dl -, d - or l -norgestrel (Ng). Blood specimens were obtained at selected time intervals. Drug related entitiesExpand
Oxazepam excretion by chlordiazepoxide-14-C-dosed dogs.
The metabolism of chlordiazepoxide was studied in dogs using the 14 C-labeled drug. Following a single 26 mg./Kg. dose, oxazepam amounting to 1.1 per cent of the dose was found in urine and 1.3 perExpand
The conversion of d-norgestrel-3-oxime-17-acetate to d-norgestrel in female rhesus monkeys.
Abstract Single intragastric 0.5 mg/kg doses of 14 C- d -norgestrel-3-oxime-17-acetate were given to female rhesus monkeys. Rapid absorption was evidenced by peak concentrations of radioactivity inExpand
Stereoselective biotransformations of dl-norgestrel and its enantiomers in the African green monkey.
The comparative metabolism of dl -, d -, and l -norgestrel was investigated in African Green Monkeys ( Cercopithecus aethiops ). Total 14C excretion in urine after a single oral dose of 14C- dlExpand
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