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Identification of CD63 as a tissue inhibitor of metalloproteinase‐1 interacting cell surface protein
This study identified CD63, a member of the tetraspanin family, as a TIMP‐1 interacting protein by yeast two‐hybrid screening. Immunoprecipitation and confocal microscopic analysis confirmed CD63Expand
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Novel functions of TIMPs in cell signaling
Tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of matrix metalloproteinases (MMPs) and the balance between MMPs/TIMPs regulates the extracellular matrix (ECM) turnover andExpand
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Modulation of endoplasmic reticulum calcium pump by Bcl-2
Members of the bcl-2 gene family encode proteins that function either to promote or to inhibit apoptosis. Despite numerous efforts, the mechanism of action of Bcl-2, an anti-apoptotic protein, isExpand
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CD29 and CD7 mediate galectin-3-induced type II T-cell apoptosis.
Galectin (Gal)-3, a M(r) 31000 member of the beta-galactoside-binding protein family, is a multifunctional protein implicated in a variety of biological functions, including tumor cell adhesion,Expand
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Platelet-derived growth factor signaling and human cancer.
  • J. Yu, C. Ustach, H. Kim
  • Medicine, Biology
  • Journal of biochemistry and molecular biology
  • 31 January 2003
Platelet-derived growth factor (PDGF) is a critical regulator of mesenchymal cell migration and proliferation. The vital functions of PDGFs for angiogenesis, as well as development of kidney, brain,Expand
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H-Ras-specific Activation of Rac-MKK3/6-p38 Pathway
Human tumors frequently exhibit constitutively activated Ras signaling, which contributes to the malignant phenotype. Mounting evidence suggests unique roles of the Ras family members, H-Ras, N-RasExpand
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Platelet‐Derived Growth Factor‐D Overexpression Contributes to Epithelial‐Mesenchymal Transition of PC3 Prostate Cancer Cells
The majority of human malignancies are believed to have epithelial origin, and the progression of cancer is often associated with a transient process named epithelial‐mesenchymal transition (EMT).Expand
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Jumonji Regulates Cardiomyocyte Proliferation via Interaction with Retinoblastoma Protein*
Jumonji (JMJ) can function as a transcriptional repressor and plays critical roles in embryonic development including heart development in mice. Although JMJ has been suggested to play a role in cellExpand
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Galectin-3 Translocates to the Perinuclear Membranes and Inhibits Cytochrome c Release from the Mitochondria
Galectin-3 is a multifunctional oncogenic protein found in the nucleus and cytoplasm and also the extracellular milieu. Although recent studies demonstrated an anti-apoptotic activity of galectin-3,Expand
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Nuclear Export of Phosphorylated Galectin-3 Regulates Its Antiapoptotic Activity in Response to Chemotherapeutic Drugs
ABSTRACT Galectin-3 (Gal-3), a member of the β-galactoside binding protein family containing the NWGR antideath motif of the Bcl-2 protein family, is involved in various aspects of cancerExpand
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