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Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity
Patients with asthma, a major public health problem, are at high risk for serious disease from influenza virus infection, but the pathogenic mechanisms by which influenza A causes airway disease andExpand
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered theExpand
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Extrathymically generated regulatory T cells control mucosal TH2 inflammation
A balance between pro- and anti-inflammatory mechanisms at mucosal interfaces, which are sites of constitutive exposure to microbes and non-microbial foreign substances, allows for efficientExpand
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The many paths to asthma: phenotype shaped by innate and adaptive immunity
Asthma is a very complex and heterogeneous disease that is characterized by airway inflammation and airway hyper-reactivity (AHR). The pathogenesis of asthma is associated with environmental factors,Expand
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IL-17 producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity
Obesity is associated with the development of asthma, which is often difficult to control. To understand the immunological pathways that lead to obesity-associated asthma, we fed mice a high-fat dietExpand
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Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity.
BACKGROUND Asthma has been considered an immunologic disease mediated by T(H)2 cells and adaptive immunity. However, clinical and experimental observations suggest that additional pathways mightExpand
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Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR‐γ signal pathways
Ginsenosides, the active component of ginseng, exerts antidiabetic and anticancer effects. This study investigated the molecular basis of ginsenoside Rg3, a red ginseng rich constituent, focusing onExpand
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Actomyosin stiffens the vertebrate embryo during crucial stages of elongation and neural tube closure
Physical forces drive the movement of tissues within the early embryo. Classical and modern approaches have been used to infer and, in rare cases, measure mechanical properties and the location andExpand
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Recruitment of the Swi/Snf Complex by Ste12-Tec1 Promotes Flo8-Mss11-Mediated Activation of STA1 Expression
ABSTRACT In the yeast Saccharomyces diastaticus, expression of the STA1 gene, which encodes an extracellular glucoamylase, is activated by the specific DNA-binding activators Flo8, Mss11, Ste12, andExpand
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Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17
Exposure to ozone, which is a major component of air pollution, induces a form of asthma that occurs in the absence of adaptive immunity. Although ozone-induced asthma is characterized by airwayExpand
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