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Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis
The complete nucleotide sequence of the linear chromosome of Streptomyces avermitilis is determined and it is revealed that an internal 6.5-Mb region in the S. avermitILis genome was highly conserved with respect to gene order and content, and contained all known essential genes but showed perfectly asymmetric structure at the oriC center.
Genome sequencing and analysis of Aspergillus oryzae
Specific expansion of genes for secretory hydrolytic enzymes, amino acid metabolism and amino acid/sugar uptake transporters supports the idea that A. oryzae is an ideal microorganism for fermentation.
Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites
- S. Ōmura, H. Ikeda, M. Hattori
- Biology, EngineeringProceedings of the National Academy of Sciences…
- 25 September 2001
Streptomyces avermitilis is a soil bacterium that carries out not only a complex morphological differentiation but also the production of secondary metabolites, one of which, avermectin, is…
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
The findings suggest that use of alternate promoters and consequent alternative use of first exons should play a pivotal role in generating the complexity required for the highly elaborated molecular systems in humans.
Complete sequencing and characterization of 21,243 full-length human cDNAs
There seems to be a slight bias against GC-rich transcripts in current gene prediction procedures in the “full-length long Japan” collection of sequenced human cDNAs.
Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens.
The results strongly suggest that the accumulation of these three types of amino acid substitutions correlates with the acquisition of thermostability and is responsible for the greater GC content of C. efficiens.
Substrate recognition by class I lysyl-tRNA synthetases: a molecular basis for gene displacement.
- M. Ibba, H. Losey, Y. Kawarabayasi, H. Kikuchi, S. Bunjun, D. Söll
- BiologyProceedings of the National Academy of Sciences…
- 19 January 1999
Genes encoding both an archaeal and a bacterial class I enzyme were able to rescue an Escherichia coli strain deficient in LysRS, indicating their ability to functionally substitute for a class II LysRS in vivo.
Three Proliferating Cell Nuclear Antigen-Like Proteins Found in the Hyperthermophilic Archaeon Aeropyrum pernix: Interactions with the Two DNA Polymerases
- K. Daimon, Y. Kawarabayasi, H. Kikuchi, Y. Sako, Y. Ishino
- BiologyJournal of bacteriology
- 1 February 2002
It is very interesting that three active PCNAs were found in one archaeal cell, and further analyses are necessary to determine whether each PCNA has specific roles, and moreover, how they reveal different functions in the cells.
Pyrococcus prefoldin stabilizes protein-folding intermediates and transfers them to chaperonins for correct folding.
- M. Okochi, Takao Yoshida, T. Maruyama, Y. Kawarabayasi, H. Kikuchi, M. Yohda
- BiologyBiochemical and biophysical research…
- 8 March 2002
A molecular chaperone prefoldin/GimC from the hyperthermophilic archaeum Pyrococcus horikoshii OT3 was characterized. Pyrococcus prefoldin protected porcine heart citrate synthase from thermal…
Thermostable Flap Endonuclease from the Archaeon,Pyrococcus horikoshii, Cleaves the Replication Fork-like Structure Endo/Exonucleolytically*
The flap endonuclease gene homologue from the hyperthermophilic archaeon, Pyrococcus horikoshii, was overexpressed in Escherichia coli and purified. The results of gel filtration indicated that this…