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  • H. Kazazian
  • Biology, Medicine
  • Science
  • 2004 (First Publication: 12 March 2004)
  • Mobile elements within genomes have driven genome evolution in diverse ways. Particularly in plants and mammals, retrotransposons have accumulated to constitute a large fraction of the genome andExpand
  • E. Ostertag, H. Kazazian
  • Biology, Medicine
  • Annual review of genetics
  • 2001 (First Publication: 1 December 2001)
  • L1 retrotransposons comprise 17% of the human genome. Although most L1s are inactive, some elements remain capable of retrotransposition. L1 elements have a long evolutionary history dating to theExpand
  • J. Goodier, L. Zhang, M. Vetter, H. Kazazian
  • Medicine, Biology
  • Molecular and Cellular Biology
  • 2007 (First Publication: 11 June 2007)
  • ABSTRACT LINE-1 retrotransposons constitute one-fifth of human DNA and have helped shape our genome. A full-length L1 encodes a 40-kDa RNA-binding protein (ORF1p) and a 150-kDa protein (ORF2p) withExpand