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Increase in sympathetic outflow by paraventricular nucleus stimulation in awake rats.
Our previous studies demonstrated that stimulation of the hypothalamic paraventricular nucleus (PVN) in anesthetized rats evoked a depressor response accompanied with a decrease in sympatheticExpand
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Sympathetic and cardiovascular actions of orexins in conscious rats.
The novel hypothalamic peptides orexin-A and orexin-B are known to induce feeding behavior when administered intracerebroventricularly, but little is known about other physiological functions. TheExpand
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Cardiovascular effects of leptin and orexins.
Leptin, the product of the ob gene, is a satiety factor secreted mainly in adipose tissue and is part of a signaling mechanism regulating the content of body fat. It acts on leptin receptors, most ofExpand
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Connections of neurons in the region of the nucleus tractus solitarius with the hypothalamic paraventricular nucleus: Their possible involvement in neural control of the cardiovascular system in rats
Extracellular recordings were made from 607 spontaneously firing neurons within the nucleus tractus solitarius (NTS) and its vicinity in urethane-anesthetized male rats. Following electricalExpand
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Responses of neurons in the insular cortex to gustatory, visceral, and nociceptive stimuli in rats.
Extracellular unit responses to baroreceptor and chemoreceptor stimulation, gustatory stimulation of the posterior tongue, electrical stimulation of the superior laryngeal (SL) nerve, and tail pinchExpand
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Differential effects of anesthetics on sympathetic nerve activity and arterial baroreceptor reflex in chronically instrumented rats.
The effects of pentobarbital sodium, chloralose, and urethane on sympathetic nerve activity and arterial baroreceptor reflex were examined using rats chronically instrumented for recordings of bloodExpand
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Orexin depolarizes rat hypothalamic paraventricular nucleus neurons.
Orexins, also called hypocretins, are newly discovered hypothalamic peptides that are thought to be involved in various physiological functions. In spite of the fact that orexin receptors, especiallyExpand
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Central actions of adrenomedullin on cardiovascular parameters and sympathetic outflow in conscious rats.
Adrenomedullin (ADM) is reported to be a peripherally acting hypotensive peptide, but its central actions are unclear. We investigated the effects of centrally administered ADM on blood pressureExpand
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CCK-8 excites oxytocin-secreting neurons in the paraventricular nucleus in rats—Possible involvement of noradrenergic pathway
Systemic administration of CCK-8 increased plasma oxytocin (OXT) level in rats anesthetized with a mixture of urethane and alpha-chloralose. Extracellular recordings were made from magnocellularExpand
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Centrally Administered Murine Leptin Stimulates Plasma Arginine-Vasopressin Secretion and Increases the Level of mRNA Expression in the Supraoptic Nucleus of Conscious Rats
The product of the ob gene protein, leptin, has been suggested to function as an endogenous mediator of the cardiovascular system via sympathetic nerve activity. Moreover, extensive distribution ofExpand
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