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The Forkhead Transcription Factor Foxo1 Bridges the JNK Pathway and the Transcription Factor PDX-1 through Its Intracellular Translocation*
It has been shown that oxidative stress and activation of the c-Jun N-terminal kinase (JNK) pathway induce the nucleocytoplasmic translocation of the pancreatic transcription factor PDX-1, whichExpand
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Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis
Type 2 diabetes is the most prevalent and serious metabolic disease all over the world, and its hallmarks are pancreatic β-cell dysfunction and insulin resistance. Under diabetic conditions, chronicExpand
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Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.
Oxidative stress is produced under diabetic conditions and possibly causes various forms of tissue damage in patients with diabetes. The aim of this study was to examine the involvement of oxidativeExpand
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Involvement of c-Jun N-terminal Kinase in Oxidative Stress-mediated Suppression of Insulin Gene Expression*
Oxidative stress, which is found in pancreatic β-cells in the diabetic state, suppresses insulin gene transcription and secretion, but the signaling pathways involved in the β-cell dysfunctionExpand
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Cisplatin-induced cell death is EGFR/src/ERK signaling dependent in mouse proximal tubule cells.
Cisplatin treatment induces extensive death of the proximal tubules in mice. We also demonstrated that treatment of immortalized mouse proximal tubule cells (TKPTS) with 25 microM cisplatin inducesExpand
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Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide
The JNK pathway is known to be activated in several tissues in the diabetic state, and is possibly involved in the development of insulin resistance and suppression of insulin biosynthesis. Here weExpand
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Activation of the Hexosamine Pathway Leads to Deterioration of Pancreatic β-Cell Function through the Induction of Oxidative Stress*
It is known well that activation of the hexosamine pathway causes insulin resistance, but how this activation influences pancreatic β-cell function remains unclear. In this study, we found that inExpand
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Involvement of Endoplasmic Reticulum Stress in Insulin Resistance and Diabetes*
Type 2 diabetes is one of the most prevalent and serious metabolic diseases in the world, and insulin resistance and pancreatic β-cell dysfunction are the hallmarks of the disease. In this study, weExpand
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Downregulation of GLP-1 and GIP Receptor Expression by Hyperglycemia
Stimulation of insulin secretion by the incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) has been found to be diminished in type 2 diabetes. WeExpand
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Modulation of the JNK Pathway in Liver Affects Insulin Resistance Status*
The c-Jun N-terminal kinase (JNK) pathway is known to be activated under diabetic conditions and to possibly be involved in the progression of insulin resistance. In this study, we examined theExpand
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