• Publications
  • Influence
Translocator Protein (18 kD) as Target for Anxiolytics Without Benzodiazepine-Like Side Effects
Keeping Calm Benzodiazepines are the most prescribed anxiolytics and are used by a broad population. However, benzodiazepines can cause unwanted side effects, including sedation, development of
A review of the evidence for the canonical Wnt pathway in autism spectrum disorders
TLDR
The available genetic information indicates that not only canonical Wnt pathway activation, but also inhibition seems to increase autism risk, which provides a logical explanation as to why both hypo- and hyperactivity may generate a similar set of behavioral and cognitive symptoms.
Activation of Meningeal 5‐HT2B Receptors: An Early Step in the Generation of Migraine Headache?
TLDR
The hypothesis that 5‐HT2B receptors located on endothelial cells of meningeal blood vessels trigger migraine headache through the formation of nitric oxide is supported.
Cloning and functional characterization of the rat stomach fundus serotonin receptor.
TLDR
A DNA segment homologous to the third exons of the serotonin 1C and 2 receptor genes was isolated from a mouse genomic library and the pharmacological profile resembled that described for the serotonin‐stimulated contraction of the stomach fundus.
Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders
TLDR
Information from tobacco smoking, vagus nerve stimulation, and cholinesterase inhibition is used to evaluate the therapeutic potential of selective α7 nAChR agonists in these inflammation-related disorders.
alpha2C-Adrenoceptor blockade by clozapine and other antipsychotic drugs.
(+)-cis-4,5,7a,8,9,10,11,11a-octahydro-7H-10-methylindolo[1,7- bc][2,6]-naphthyridine: a 5-HT2C/2B receptor antagonist with low 5-HT2A receptor affinity.
TLDR
The indolonaphthyridine 8 is described as a selective 5- HT2C/2B vs 5-HT2A receptor antagonist and behaved as an antagonist on the 5-ht-induced accumulation of inositol phosphates in pig choroid plexus cells.
...
...