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A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
The chromosome 9p21 amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) locus contains one of the last major unidentified autosomal-dominant genes underlying these common… Expand
Muscle strain injuries.
- T. Järvinen, M. Kääriäinen, M. Järvinen, H. Kalimo
- Current opinion in rheumatology
- 1 March 2000
Muscle injuries--lacerations, contusions or strains--are by far the most common injuries in sports. After first aid following the RICE principle (Rest, Ice, Compression and Elevation), therapy must… Expand
Muscle injuries: optimising recovery.
- T. Järvinen, T. Järvinen, +4 authors M. Järvinen
- Best practice & research. Clinical rheumatology
- 1 April 2007
Muscle injuries are one of the most common traumas occurring in sports. Despite their clinical importance, there are only a few clinical studies on the treatment of muscle injuries. Lack of clinical… Expand
Interstitial chemotherapy with carmustine-loaded polymers for high-grade gliomas: a randomized double-blind study.
OBJECTIVE To find out the effect of carmustine (bischloroethyl-nitrosourea) combined with a biodegradable polymer in the treatment of malignant (Grades III and IV) gliomas, applied locally, at the… Expand
A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1
We describe a novel variant of Alzheimer's disease (AD) in a Finnish pedigree with 17 affected individuals of both sexes in three generations. The disease is characterized by progressive dementia… Expand
Notch Signaling Regulates Platelet-Derived Growth Factor Receptor-β Expression in Vascular Smooth Muscle Cells
Notch signaling is critically important for proper architecture of the vascular system, and mutations in NOTCH3 are associated with CADASIL, a stroke and dementia syndrome with vascular smooth muscle… Expand
Healing of skeletal muscle injury: an ultrastructural and immunohistochemical study.
- T. Hurme, H. Kalimo, M. Lehto, M. Järvinen
- Chemistry, Medicine
- Medicine and science in sports and exercise
- 1 July 1991
The healing of gastrocnemius muscle injury induced with a spring-loaded hammer in rats was analysed ultrastructurally and immunohistochemically. The ends of the ruptured myofibers retracted, which… Expand
- T. Järvinen, T. Järvinen, M. Kääriäinen, H. Kalimo, M. Järvinen
- The American journal of sports medicine
- 1 May 2005
Muscle injuries are one of the most common traumas occurring in sports. Despite their clinical importance, few clinical studies exist on the treatment of these traumas. Thus, the current treatment… Expand
Satellite cell proliferation and the expression of myogenin and desmin in regenerating skeletal muscle: evidence for two different populations of satellite cells.
- J. Rantanen, T. Hurme, R. Lukka, J. Heino, H. Kalimo
- Biology, Medicine
- Laboratory investigation; a journal of technical…
- 1 March 1995
BACKGROUND Regeneration of mature skeletal muscle recapitulates closely fetal myogenesis. It is initiated by activation of the reserve myogenic precursor cells, the satellite cells, which… Expand
Congruence between NOTCH3 mutations and GOM in 131 CADASIL patients
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary subcortical vascular dementia. It is caused by mutations in NOTCH3… Expand