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Galactosylation by use of β-galactosidase: Enzymatic syntheses of disaccharide nucleosides
Abstract The synthesis of various galactose containing disaccharide nucleosides has been achieved by utilizing the transgalactosylation potential of s-galactosidase from Aspergillus oryzae. Thus,Expand
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2-Deprenyl-Rheediaxanthone B Isolated from Metaxya rostrata Induces Active Cell Death in Colorectal Tumor Cells
Metaxya rostrata C. Presl (Metaxyaceae) is a common tree fern in Central and South America that is used for the treatment of intestinal ulcers and tumours in ethnic medicine. Using aExpand
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Chemical and Pharmacological Investigations of Metaxya rostrata
In a bioassay-guided approach the chemical composition of rhizomes of Metaxya rostrata (Kunth C. Presl) was studied for the first time. Investigations of the cytotoxicity of extracts and fractions onExpand
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Rapid structural identification of cytotoxic bufadienolide sulfates in toad venom from Bufo melanosticus by LC-DAD-MS(n) and LC-SPE-NMR.
Toad venom, namely, "Chansu" in China, has been widely used for the treatment of heart failure, sores, pains, and various cancers. Upon LC-MS analysis of the venom from Bufo melanosticus collected inExpand
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The 12,13-diol cyclization approach for a truly stereocontrolled total synthesis of epothilone B and the synthesis of a conformationally restrained analogue.
A highly convergent and stereocontrolled synthesis of epothilone B (1) has been developed. The epoxide moiety in 1 was generated by regioselective mesylation and base treatment of the 12,13-diol 30Expand
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Chemical Composition of Scrophularia lucida and the Effects on Tumor Invasiveness in Vitro
A detannified methanolic extract of Scrophularia lucida L. attenuated the formation of cancer cell-induced circular chemorepellent induced defects (CCIDs) in the lymph endothelial cell barrier, whichExpand
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Synthesis of 5‐(Fluorophenyl)tocopherols as Novel Dioxin Receptor Antagonists
γ-Tocopherol, a component of the essential nutrient mixture commonly designated as vitamin E, was chemically combined with differently substituted monofluoro- and difluorophenyl moieties to produceExpand
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ENZYMES IN ORGANIC CHEMISTRY 7.[1] EVALUATION OF HOMOCHIRAL t-BUTYL(PHENYL)PHOSPHINOTHIOIC ACID FOR THE DETERMINATION OF ENANTIOMERIC EXCESSES AND ABSOLUTE CONFIGURATIONS OF α-SUBSTITUTED PHOSPHONATES
Abstract α-Hydroxy-, α-acetoxy-. α-chloroacetoxg, α-azido-, α-phthalimidooxy-, and α-aminooxy-phosphonates are investigated by 1H and 31P NMR spectroscopy in the presence of homochiralExpand
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Biosynthesis of natural products with a P–C bond. Part 6. Preparation of deuterium- and carbon-13-labelled L-alanyl- and L-alanyl-L-alanyl-(2-aminoethyl)phosphonic acids and their use in biosynthetic
(2-Aminoethyl)phosphonic acid (AEP) is not taken up by Streptomyces fradiae in the biosynthesis of fosfomycin. Attachment of L-alanine or L-alanyl-L-alanine to the amino group of deuteriated AEPExpand
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Two Unusual Methylidenecyclopropane Glucosides from Metaxya rostrata C.Presl
Two new natural compounds, (1R,2E)-2-(6-hydroxyhexylidene)cyclopropyl-β-D-glucopyranoside (1) and (6E)-6-[(2R)-2-(β-D-glucopyranosyloxy)cyclopropylidene]hexanoic acid (2), glucosides of a very rareExpand
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