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Heteroannulation of nitroketene N,S-arylaminoacetals with POCl3: a novel highly regioselective synthesis of unsymmetrical 2,3-substituted quinoxalines.
[reaction: see text]. A novel regioselective route for the synthesis of substituted and fused 3-chloro-2-(methylthio)quinoxalines through POCl3-mediated heteroannulation of a range ofExpand
Synthesis and evaluation of pyrazolo[3,4-b]pyridines and its structural analogues as TNF-alpha and IL-6 inhibitors.
In the present article, we have synthesized three different series of pyrazolo[3,4-b]pyridines and their structural analogues using novel synthetic strategy involving one-pot condensation ofExpand
An expeditious synthesis of substituted and annelated pyrido[2,3-b]indoles
An efficient and versatile synthesis of substituted and annelated pyrido[2,3-b]indoles (α-carboline) involving conjugate displacement on α-oxoketene dithioacetals by 1-methyl-2-oxoindole enolateExpand
Structure and thermal isomerization of the adducts formed in the reaction of cyclohexyl isocyanide with dimethyl acetylenedicarboxylate
Reaction of cyclohexyl isocyanide (1d) with dimethyl acetylenedicarboxylate (DMAD) gave a mixture of products such as the cyclopenta[b]pyridine derivatives 14 (28%) and 19 (1%), theExpand
Studies on regioselective addition of benzylic organometallics to α-oxoketene dithioacetals in our aromatic annelation protocol
Abstract The α-oxoketene dithioacetals derived from various acyclic and cyclic active methylene ketones are shown to undergo either 1,2- or sequential 1,4- and 1,2-addition with various substitutedExpand
Regioselective synthesis of 3(or 5)‐styryl‐/(4‐aryl‐1,3‐butadienyl)‐/(6‐aryl‐1,3,5‐hexatrienyl)‐5(or 3)‐(methylthio)isoxazoles and pyrazoles via α‐oxoketene dithioacetals
The regioselective synthesis of the title isoxazoles and pyrazoles through cyclocondensation of oxoketene dithioacetals with either hydroxylamine or hydrazine hydrate under controlled conditions isExpand
4-Alkoxy-3-cyano-2(1H)-pyridones and 5-Alkoxyisoxazoles and Their Aryl Substituted and Annulated Derivatives from Acylketene O,S-Acetals
The title pyridones 2 and 5 and the isoxazoles 3 are obtained in moderate to good yields by cyclocondensation of the appropriate acylketene O,S-acetals 1 or 4 with cyanoacetamide and hydroxylamineExpand
Efficient routes to pyrazolo[3,4-b]indoles and pyrazolo[1,5-a]benzimidazoles via palladium- and copper-catalyzed intramolecular C-C and C-N bond formation.
Efficient synthetic routes to pyrazolo[3,4-b]indoles and pyrazolo[1,5-a]benzimidazoles via intramolecular palladium- and copper-catalyzed cyclization of 1-aryl/1-unsubstitutedExpand
Regioselective synthesis of 1-aryl-3,4-substituted/annulated-5-(methylthio)pyrazoles and 1-aryl-3-(methylthio)-4,5-substituted/annulated pyrazoles.
[reaction: see text] Highly efficient and regioselective synthesis of 1-aryl-3,4-substituted/annulated-5-(methylthio)pyrazoles and 1-aryl-3-(methylthio)-4,5-substituted/annulated pyrazoles has beenExpand
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