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Metabolomics in toxicology and preclinical research.
Three working groups addressing questions regarding 1) metabolomics for in vitro studies 2) the appropriate use of metabolomics in systems toxicology, and 3) use of metabolites in a regulatory context are addressed. Expand
Workers of the stingless bee Melipona scutellaris are more similar to males than to queens in their cuticular compounds
The cuticular compounds from the wings of workers, males and queens of the stingless bee Melipona scutellaris Latreille 1811 were analysed by combined gas chromatography-mass spectrometry. This hasExpand
Application of laser postionization secondary neutral mass spectrometry/time-of-flight secondary ion mass spectrometry in nanotoxicology: visualization of nanosilver in human macrophages and cellular
A novel laser postionization secondary neutral mass spectrometry (Laser-SNMS) approach is introduced and this method superior to the widely applied confocal Raman and transmission electron microscopy is proved and characteristic fingerprints in the lipid pattern of the cellular membrane indicative of oxidative stress and membrane fluidity changes are demonstrated. Expand
Freshwater dispersion stability of PAA-stabilised cerium oxide nanoparticles and toxicity towards Pseudokirchneriella subcapitata.
It is indicated that the increased dispersion stability of PAA-CeO₂ leads to an increase in toxicity compared to pristine non-stabilised forms. Expand
Comparative Survey of Abdominal Gland Secretions of the Ant Subfamily Ponerinae
All of the 27 known analyses of Dufour glands, 21 analyses of venom glands, and 4 of pygidial glands of workers of ponerine ant species have been brought together in order to seek some pattern in the type of glandular contents. Expand
Chemical basis for inter-colonial aggression in the stingless bee Scaptotrigona bipunctata (Hymenoptera: Apidae).
Inter-colonial aggression was tested using three colonies of Scaptotrigona bipunctata in a natural setting when their nests were moved and by artificial contact between individuals to show that seven of the identified surface compounds are enough to separate workers from colonies A and B from each other. Expand
Investigations on the heat transfer of boiling binary refrigerant mixtures
Resume La transmission de chaleur lors de l'ebullition nucleee a ete determinee experimentalement pour les melanges R-12/R-113, R-22/R-12, R-13/R-12, R-13/R-22 et R-23/R-13. Aux fins de comparaisonExpand
Pathway and time-resolved benzo[a]pyrene toxicity on Hepa1c1c7 cells at toxic and subtoxic exposure.
The comprehensive chemical, proteome and metabolomic data enabled the identification of effects on the pathway level in a time-resolved manner and also protein synthesis, lipid metabolism, and membrane dysfunction were identified as B[a]P specific effects. Expand
On the cytotoxity of oxidized phytosterols isolated from photoautotrophic cell cultures of Chenopodium rubrum tested on meal-worms Tenebrio molitor
A bioassay to determine the cytotoxity of sterol oxidation products by measuring the mortality of meal-worms after injection of diluted test compounds is described and proposed biological function of oxidized phytosterols is discussed. Expand
Toxicity of silver nanoparticles in human macrophages: uptake, intracellular distribution and cellular responses
Silver nanoparticles (SNP) are among the most commercialized nanoparticles worldwide. They can be found in many diverse products, mostly because of their antibacterial properties. Despite itsExpand