Ethanol as an alternative fuel from agricultural, industrial and urban residues
Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells.
- K. Ye, Y. Ke, H. Joshi
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 17 February 1998
It is shown that noscapine binds stoichiometrically to tubulin, alters its conformation, affects microtubule assembly, and arrests mammalian cells in mitosis, and causes apoptosis in many cell types.
Ethanol Production from Sweet Sorghum Syrup for Utilization as Automotive Fuel in India
Ethanol demand is increasing drastically in the present time due to its blending in automotive fuels, which is desirable for getting clean exhaust and fuel sufficiency. The higher cost of cultivation…
Attachment and tension in the spindle assembly checkpoint
This work has provided novel insights into the molecular mechanisms through which the spindle assembly checkpoint is regulated by both the attachment of chromosomes to kinetochore microtubules and the tension exerted on Kinetochores.
Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation.
Two brominated derivatives of noscapine, 5- Br-nosc and reduced 5-bromonoscapine (Rd 5-Br- nosc) have higher tubulin binding activity than nos capine and affect tubulin polymerization differently from noscapINE, and are able to arrest cell cycle progression at mitosis at concentrations much lower than Noscapine.
Reversal of P-glycoprotein-mediated multidrug resistance in cancer cells by the c-Jun NH2-terminal kinase.
It is shown that adenovirus-mediated enhancement of the c-Jun NH2-terminal kinase (JNK) reduces the level of P-glycoprotein in a dose- and time-dependent manner and dramatically enhances the sensitivity of MDR cancer cells to chemotherapeutic agents.
Noscapine alters microtubule dynamics in living cells and inhibits the progression of melanoma.
Noscapine significantly inhibits the progression of melanoma cells through alterations in microtubule dynamics, with no detected toxicity to the host, and could be a valuable chemotherapeutic agent, alone or in combination, for the treatment of advanced melanoma.
Paclitaxel-resistant Human Ovarian Cancer Cells Undergo c-Jun NH2-terminal Kinase-mediated Apoptosis in Response to Noscapine*
These results suggest that the JNK pathway plays an essential role in microtubule inhibitor-induced apoptosis and indicate a great potential for noscapine in the treatment of paclitaxel-resistant human cancers.
Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses
- Y. Ke, K. Ye, H. Grossniklaus, D. Archer, H. Joshi, J. Kapp
- Biology, MedicineCancer Immunology and Immunotherapy
- 19 June 2000
Oral noscapine has the potential to be an effective chemotherapeutic agent for the treatment of human cancer and showed little or no toxicity to kidney, liver, heart, bone marrow, spleen or small intestine at tumor-suppressive doses.
Noscapine Crosses the Blood-Brain Barrier and Inhibits Glioblastoma Growth
It is shown that noscapine inhibits the proliferation of rat C6 glioma cells in vitro and effectively crosses the blood-brain barrier at rates similar to the ones found for agents such as morphine and [Met]enkephalin that have potent central nervous system activity.