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Gap junctions in cardiovascular disease.
Using a simple model of human ventricular myocardium, it is found that quantitative remodeling data extracted from the literature gave rise to only small to moderate changes in conduction velocity and the anisotropy ratio. Expand
Differences in gap junction channels between cardiac myocytes, fibroblasts, and heterologous pairs.
- M. Rook, A. V. van Ginneken, B. de Jonge, A. el Aoumari, D. Gros, H. Jongsma
- Biology, Medicine
- The American journal of physiology
- 1 November 1992
The results suggest the existence of two gap junction proteins between neonatal rat cardiocytes, connexin43 and another yet unidentified connexon, and an alternative explanation (cell-specific regulation of the conductance of connex in43 channels) is discussed. Expand
Architectural and functional asymmetry of the His-Purkinje system of the murine heart.
This investigation provides positive evidence of the asymmetry of the His-Purkinje system of the adult mouse, and the first patch-clamp recording data on murine cardiac Purkinje cells. Expand
Distribution of connexin37, connexin40 and connexin43 in the aorta and coronary artery of several mammals
It is concluded that Cx40 is the constitutive vascular gap junction protein in situ and guarantees cell coupling between cells in the vessel wall and the differentiated distribution of both Cx37 and Cx43 suggests they are involved in more dynamic processes. Expand
Electrical conductance of mouse connexin45 gap junction channels is modulated by phosphorylation.
Experiments show that electrical intercellular conductance via Cx45 gap junction channels is differentially regulated by phosphorylation, however, regulation does not act by changing single channel conductance, but most likely by modulation of the open probability of Cx 45 gap junction channel channels. Expand
TPA increases conductance but decreases permeability in neonatal rat cardiomyocyte gap junction channels.
- B. Kwak, T. V. van Veen, L. Analbers, H. Jongsma
- Biology, Medicine
- Experimental cell research
- 1 October 1995
Results point to the opposite modulation of electrical and metabolic coupling of cardiac cells evoked by TPA, which suggests that permeability and single channel conductance of connexin 43 channels are parallely related. Expand
Reverse Structural and Gap-Junctional Remodeling After Prolonged Atrial Fibrillation in the Goat
Recovery from structural remodeling after 4 mo AF is a slow process and is still incomplete 4 mo post-AF, compared with seconds in the SR group. Expand
Beating irregularity of single pacemaker cells isolated from the rabbit sinoatrial node.
It is concluded that fluctuations in interbeat interval of single sinoatrial node pacemaker cells indeed are due to the stochastic open-close kinetics of the membrane ionic channels. Expand
Differential regulation of distinct types of gap junction channels by similar phosphorylating conditions.
- B. Kwak, M. M. Hermans, H. D. de Jonge, S. Lohmann, H. Jongsma, M. Chanson
- Biology, Medicine
- Molecular biology of the cell
- 1 December 1995
Results show that distinct types of gap junction channels are differentially regulated by similar phosphorylating conditions, which may be of physiological importance during modulation of cell-to-cell communication of more complex cell systems. Expand
Pacemaker activity of the rabbit sinoatrial node. A comparison of mathematical models.
A more accurate model, describing the pacemaker activity of a single pacemaker cell isolated from the rabbit sinoatrial node, was constructed and is used to discuss the relative contribution of membrane current components to the slow diastolic depolarization phase of the action potential. Expand