Human liver UDP-glucuronosyltransferase isoforms involved in the glucuronidation of 7-ethyl-10-hydroxycamptothecin
- N. Hanioka, S. Ozawa, H. Jinno, M. Ando, Y. Saito, J. Sawada
- Biology, ChemistryXenobiotica; the fate of foreign compounds in…
- 1 January 2001
It is demonstrated that at least four UGT1A isoforms are responsible for SN-38 glucuronidation in human livers, and suggested that the role and contribution of each differ substantially.
Functional characterization of cytochrome P450 2B6 allelic variants.
Results may mean that Lys262 in combination with other amino acid residues such as Gln172 and Arg487 is associated with the CYP2B6 function and that the genetic polymorphism of CYP 2B6 leads to interindividual differences in xenobiotic metabolism.
Identification of novel alternative splice variants of human constitutive androstane receptor and characterization of their expression in the liver.
Four novel splice variants in the ligand-binding domain (LBD) of hCAR were found and it was revealed that the hepatic expression of SV2 was almost comparable with that of SV0 (approximately 40%), whereas other variants accounted for 6 to 10% of the total hCAR transcripts.
UGT1A1 Haplotypes Associated with Reduced Glucuronidation and Increased Serum Bilirubin in Irinotecan‐administered Japanese Patients with Cancer
Determination of UDP-glucuronosyltransferase UGT1A6 activity in human and rat liver microsomes by HPLC with UV detection.
RACIAL VARIABILITY IN HAPLOTYPE FREQUENCIES OF UGT1A1 AND GLUCURONIDATION ACTIVITY OF A NOVEL SINGLE NUCLEOTIDE POLYMORPHISM 686C> T (P229L) FOUND IN AN AFRICAN-AMERICAN
Differences in haplotype distribution patterns among the three populations suggest the possibility of ethnic differences in toxicity profiles of drugs detoxicated by UGT1A1, and a novel SNP, 686C>T (P229L), was found in an African-American.
Haplotype structures of the UGT1A gene complex in a Japanese population
Important haplotypes and their linkages were identified among the UGT1A gene blocks (and segments), which should be considered in pharmacogenetic studies.
Interaction of 2,4,4'-trichloro-2'-hydroxydiphenyl ether with microsomal cytochrome P450-dependent monooxygenases in rat liver.
Functional Characterization of Human UDP-Glucuronosyltransferase 1A9 Variant, D256N, Found in Japanese Cancer Patients
- H. Jinno, M. Saeki, J. Sawada
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 August 2003
Results clearly indicate that the D256N variant is essentially nonfunctional with regard to SN-38 glucuronidation and highlight the importance of further studies into the potential influence of UGT1A9 D 256N variant to irinotecan metabolism in vivo.
In vitro metabolism of chlorotriazines: characterization of simazine, atrazine, and propazine metabolism using liver microsomes from rats treated with various cytochrome P450 inducers.
- N. Hanioka, H. Jinno, T. Tanaka-Kagawa, T. Nishimura, M. Ando
- Chemistry, BiologyToxicology and Applied Pharmacology
- 1 May 1999
The results suggest that the inducibility in metabolism of SIZ, ATZ, and PRZ is different between N-monodealkylation and isopropylhydroxylation in all rat liver microsomes and that the Eadie-Hofstee analyses suggest that they are markedly induced by 3-methylcholanthrene, phenobarbital, and pyridine.