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Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1
TLDR
Modulating GLP-1 secretion in gut “taste cells” through the same mechanisms used by taste cells of the tongue may provide an important treatment for obesity, diabetes and abnormal gut motility.
Modulation of taste sensitivity by GLP‐1 signaling
TLDR
It is reported that glucagon‐like peptide‐1 (GLP‐1) signaling in taste buds modulates taste sensitivity in behaving mice, and this findings suggest a novel paracrine mechanism for the regulation of taste function.
Peptide YY is secreted after oral glucose administration in a gender-specific manner.
TLDR
Findings show that PYY and GLP-1 are colocalized and cosecreted from L cells and that total secretion of PYY is higher in females than in males, but fasting PYY levels and PYY secretion in response to oral glucose were not in any way correlated with BMI.
Characterization of a Thermostable l-Arabinose (d-Galactose) Isomerase from the Hyperthermophilic Eubacterium Thermotoga maritima
TLDR
AraA gene encoding l-arabinose isomerase (AI) from the hyperthermophilic bacterium Thermotoga maritima was cloned and overexpressed in Escherichia coli as a fusion protein containing a C-terminal hexahistidine sequence and had greater thermostability and higher catalytic efficiency than its mesophilic counterparts at elevated temperatures.
Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways
TLDR
This study demonstrates that activation of gut-expressed bitter taste receptors stimulates GLP-1 secretion in a PLC-dependent manner in diabetic mice, and identifies signalling pathways triggered by the denatonium benzoate (DB)-activated bitter receptors.
Global transcriptomic response of Pseudomonas aeruginosa to chlorhexidine diacetate.
TLDR
This study presents, for the first time, the transcriptomic response of P. aeruginosa to 0.008 mM CHX and provides insights into the mechanism of action of other biguanide disinfectants which can be used for the development of more efficient disinfectants.
Oldenlandia diffusa Ameliorates Dextran Sulphate Sodium-Induced Colitis Through Inhibition of NF-κB Activation.
TLDR
Experimental evidence that OD might be a useful therapeutic medicine for patients with UC is provided, and Hentriacontane, a constituent of OD, attenuated weight loss, colon shortening, and levels of IL-6 caused by DSS.
Eucommiae cortex inhibits TNF-α and IL-6 through the suppression of caspase-1 in lipopolysaccharide-stimulated mouse peritoneal macrophages.
TLDR
The findings of the study show that EC inhibits the LPS-induced production of tumor necrosis factor-alpha and interleukin-6 and indicates that EC has a potential in the treatment of inflammatory diseases.
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