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Genome sequence of the Brown Norway rat yields insights into mammalian evolution
The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genomeExpand
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Comparative recombination rates in the rat, mouse, and human genomes.
Levels of recombination vary among species, among chromosomes within species, and among regions within chromosomes in mammals. This heterogeneity may affect levels of diversity, efficiency ofExpand
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Zebrafish genetic map with 2000 microsatellite markers.
The zebrafish is the first vertebrate organism used for large-scale genetic screens seeking genes critical to development. These screens have been quite successful, with more than 1800 recessiveExpand
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Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases
Targeted gene disruption in rats paves the way for new human disease models. The toolbox of rat genetics currently lacks the ability to introduce site-directed, heritable mutations into the genome toExpand
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Gene Expression Profiling Leads to Identification of GLI1-binding Elements in Target Genes and a Role for Multiple Downstream Pathways in GLI1-induced Cell Transformation*
The zinc finger transcription factor GLI1, which mediates Sonic hedgehog signaling during development, is expressed in several human cancers, including basal cell carcinoma, medulloblastoma, andExpand
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Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome.
Recent research has emphasized the importance of the metabolic cluster, which includes glucose intolerance, dyslipidemia, and high blood pressure, as a strong predictor of the obesity-relatedExpand
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A microsatellite genetic linkage map for zebrafish (Danio rerio)
We have constructed a zebrafish genetic linkage map consisting of 705 simple sequence-length polymorphism markers (SSLPs). The map covers 2350 centimorgans (cM) of the zebrafish genome with anExpand
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The Gene Ontology project in 2008
The Gene Ontology (GO) project (http://www.geneontology.org/) is a collaborative effort to develop and use ontologies to support biologically meaningful annotation of genes and their products in a wide variety of organisms. Expand
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Distribution and functional impact of DNA copy number variation in the rat
The abundance and dynamics of copy number variants (CNVs) in mammalian genomes poses new challenges in the identification of their impact on natural and disease phenotypes. We used computational andExpand
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The Collaborative Cross, a community resource for the genetic analysis of complex traits
The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouseExpand
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