• Publications
  • Influence
The Fate of the Oxidizing Tyrosyl Radical in the Presence of Glutathione and Ascorbate
Cellular systems contain as much as millimolar concentrations of both ascorbate and GSH, although the GSH concentration is often 10-fold that of ascorbate. It has been proposed that GSH andExpand
  • 77
  • 4
The metabolism of 17 beta-estradiol by lactoperoxidase: a possible source of oxidative stress in breast cancer.
Electron spin resonance (ESR) spectroscopy and oxygen consumption measurements using a Clark-type oxygen electrode have been used to study the metabolism of the estrogen 17 beta-estradiol byExpand
  • 105
  • 1
N-acyl dehydroalanines scavenge oxygen radicals and inhibit in vitro free radical mediated processes.
N-substituted dehydroalanines react with and scavenge oxygen radicals. One of those compounds, the para-methoxyphenylacetyl dehydroalanine derivative, indexed as AD-5, inhibits the reduction ofExpand
  • 9
  • 1
Identification of the free radical formed by addition of hydroxyl radical to dehydroalanine compounds.
N-substituted dehydroalanines, a class of compounds with both acceptor and donor substituents (ADs), react with and scavenge oxygen radicals. Interest in these compounds is based on their potentialExpand
  • 4
  • 1
Free radical intermediates during peroxidase oxidation of 2-t-butyl-4-methoxyphenol, 2,6-di-t-butyl-4-methylphenol, and related phenol compounds.
2-t-butyl-4-methoxyphenol (BHA) and 2,6-di-t-butyl-4-methylphenol (BHT) are widely used antioxidant food additives that are generally recognized as safe by the Food and Drug Administration.Expand
  • 50
In vitro free radical metabolism of phenolphthalein by peroxidases.
Phenolphthalein, a widely used laxative, is the active ingredient in more than a dozen commercial nonprescription formulations. Fast-flow EPR studies of the reaction of phenolphthalein withExpand
  • 29
  • PDF
L-tryptophan radical cation electron spin resonance studies: connecting solution-derived hyperfine coupling constants with protein spectral interpretations.
Fast-flow electron spin resonance (ESR) spectroscopy has been used to detect a free radical formed from the reaction of l-tryptophan with Ce (4+) in an acidic aqueous environment. ComputerExpand
  • 25
The one-electron oxidation of porphyrins to porphyrin pi-cation radicals by peroxidases: an electron spin resonance investigation.
For the first time, the enzymatic one-electron oxidation of several naturally occurring and synthetic water-soluble porphyrins by peroxidases was investigated by ESR and optical spectroscopy. The ESRExpand
  • 11
Free Radical Metabolism of Methyleugenol and Related Compounds
Methyleugenol, the methyl ether of eugenol, both of which are flavorant constituents of spices, has been listed by the National Toxicology Program’s Report on Carcinogens as reasonably anticipated toExpand
  • 6
Fast-flow EPR spectroscopic observation of the isoniazid, iproniazid, and phenylhydrazine hydrazyl radicals.
Hydrazyl radical intermediates have been suggested as important intermediates in the biochemistry of hydrazides and hydrazines. Although spin-trapping studies have intercepted those speciesExpand
  • 14