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Different ploidy levels of megakaryocytes generated from peripheral or cord blood CD34+ cells are correlated with different levels of platelet release.
TLDR
The data indicate the inability of the CB-MKs to progress in the endomitotic process and a direct correlation between DNA content and platelet production. Expand
Multicenter evaluation of a new chromogenic factor X assay in plasma of patients on oral anticoagulants.
Abstract A new factor X (FX) assay based on the chromogenic substrate S-2337 was compared with the coagulation screening method Thrombotest (TT) in 1431 plasma samples from 188 patients followed upExpand
Hemophilia B with inhibitor: molecular analysis of the subtotal deletion of the factor IX gene.
TLDR
The structure of factor IX gene was analyzed in a hemophilia B patient with inhibitor and a large subtotal deletion of the gene was observed. Expand
Long-term platelet production assessed in NOD/SCID mice injected with cord blood CD34+ cells, thrombopoietin-amplified in clinical grade serum-free culture.
TLDR
Platelet number obtained is within the minimum level considered sufficient for hemostasis, and amplified cells maintain their self-renewal capacity and multilineage potential differentiation, and transplantation of TPO-expanded CB cells has the potential favoring both platelet recovery and human engraftment. Expand
Induction of Dopaminergic Neurons From Human Wharton's Jelly Mesenchymal Stem Cell by Forskolin
TLDR
Findings show that hWJMSC may be represent an optimal therapeutic strategy for neurological diseases and upregulation of the neurotrophin Trk receptors related to the high release of brain‐derived neurotrophic factor is promoted. Expand
Cord blood CD34+ cells expanded on Wharton's jelly multipotent mesenchymal stromal cells improve the hematopoietic engraftment in NOD/SCID mice
This study aims to investigate the capability of Wharton's jelly multipotent mesenchymal stromal cells (WJ‐MSC) to support the in vitro expansion of hematopoietic stem/progenitor cells (HSPC) derivedExpand
Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population
TLDR
The results indicate that the MEK/ERK pathway plays a prominent role in maintaining the stem-like phenotype of RD cells, their survival and their innate radioresistance, thereby providing a promising therapy for embryonal rhabdomyosarcoma. Expand
Hereditary thrombophilia: identification of nonsense and missense mutations in the protein C gene.
TLDR
The structure of the gene for protein C, an anticoagulant serine protease, was analyzed in 29 unrelated patients with hereditary thrombophilia and protein C deficiency and identified a nonsense and a missense mutation that may explain the protein C-deficiency phenotype of heterozygotes in the two pedigrees. Expand
Factor VII Deficiency: Immunological Characterization of Genetic Variants and Detection of Carriers
TLDR
There was no correlation between the presence of factor VII:Ag and either the clinical picture or the specific function as studied with the Km calculations. Expand
Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population
TLDR
The results indicate that the MEK/ERK pathway plays a prominent role in maintaining the stem-like phenotype of RD cells, their survival and their innate radioresistance, thereby providing a promising therapy for embryonal rhabdomyosarcoma. Expand
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