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Distinct DNA methylomes of newborns and centenarians
TLDR
This study constitutes a unique DNA methylation analysis of the extreme points of human life at a single-nucleotide resolution level and demonstrated DNA methylomes in the crossroad between the newborn and the nonagenarian/centenarian groups. Expand
Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer
TLDR
An extensive catalogue of human DNA methylomes at base resolution is developed to better understand the regulatory functions of DNA methylation beyond those of proximal promoter gene regions. Expand
Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR
TLDR
It is found that epigenetic reactivation of TBC1D16-47KD is associated with poor clinical outcome in melanoma, while conferring greater sensitivity to BRAF and MEK inhibitors and RAB5C is identified as a new TBC 1D16 target and it is shown that it regulates EGFR in melanomas cells. Expand
DNA methylation profiling in breast cancer discordant identical twins identifies DOK7 as novel epigenetic biomarker
TLDR
Using whole blood from 15 twin pairs discordant for breast cancer and high-resolution DNA methylation analysis, 403 differentially methylated CpG sites including known and novel potential breast cancer genes are identified, suggesting a role as a powerful blood-based biomarker as well as providing insights into breast cancer pathogenesis. Expand
Epigenetic Disruption of the PIWI Pathway in Human Spermatogenic Disorders
TLDR
Overall, the data suggest that DNA methylation has a role in the control of gene expression in spermatogenesis and its imbalance contributes to an unsuccessful germ cell development that might explain a group of male infertility disorders. Expand
A comprehensive DNA methylation profile of epithelial-to-mesenchymal transition.
TLDR
The identified DNA methylation markers of EMT were present in primary mammary tumors in association with the epithelial or the mesenchymal phenotype of the studied breast cancer samples, suggesting the existence of a dynamic EMT process suggests the involvement of epigenetic shifts in the phenotype. Expand
Non-coding RNAs, epigenetics, and cancer: tying it all together
TLDR
How non-coding RNAs (ncRNAs) are epigenetically regulated in cancer and metastases is discussed and consequently how ncRNAs participate in the sculpting of the epigenetic profile of a cancer cell, thus modulating the expression of other RNA molecules. Expand
BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma
TLDR
It is demonstrated that inhibition of BMP signaling is the initial event in reprogramming, resulting in activation of the pluripotency-associated genes and NODAL signaling and it is proposed that reprograming of seminomas to ECs is a multi-step process. Expand
Epigenetic loss of the PIWI/piRNA machinery in human testicular tumorigenesis
TLDR
This work has studied the putative existence of epigenetic aberrations in the activity of PIWI proteins, an Argonaute family protein subclass, and the small regulatory PIWI-interacting RNAs (piRNAs) in testicular cancer, as the PIWI/piRNA pathway plays a critical role in male germline development. Expand
CpG island hypermethylation-associated silencing of small nucleolar RNAs in human cancer
TLDR
Results of a DNA methylation microarray platform in a comprehensive collection of normal tissues, cancer cell lines and primary malignancies demonstrated that the observed hypermethylation of snoRNAs was a common feature of various tumor types, particularly in leukemias. Expand
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