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Fibrinogen and β-Amyloid Association Alters Thrombosis and Fibrinolysis: A Possible Contributing Factor to Alzheimer's Disease
Alzheimer's disease peptide β-amyloid interacts with fibrinogen and induces its oligomerization
- H. J. Ahn, D. Zamolodchikov, M. Cortés-Canteli, E. Norris, J. Glickman, S. Strickland
- BiologyProceedings of the National Academy of Sciences
- 22 November 2010
It is indicated that the interaction between Aβ and fibrinogen may be an important contributor to the vascular abnormalities found in AD.
Fibrinogen and altered hemostasis in Alzheimer's disease.
- M. Cortés-Canteli, D. Zamolodchikov, H. J. Ahn, S. Strickland, E. Norris
- Biology, MedicineJournal of Alzheimer's disease : JAD
It is found that Aβ and fibrin(ogen) interact, and their binding leads to increasedfibrinogen aggregation, Aβ fibrillization, and the formation of degradation-resistant fibrIn clots, which could contribute to Aβ deposition, decreased cerebral blood flow, exacerbated neuroinflammation, and eventual neurodegeneration in AD.
A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer’s disease mice
- H. J. Ahn, J. Glickman, S. Strickland
- Biology, ChemistryThe Journal of experimental medicine
- 2 June 2014
Pharmacological disruption of the interaction between fibrinogen and β-amyloid reduces vascular amyloid deposition and improves cognition in a mouse model of Alzheimer’s disease.
Biochemical and structural analysis of the interaction between β-amyloid and fibrinogen.
The central region of Aβ42 is identified as the most critical region for the Aβ-fibrinogen interaction, which can be inhibited by specific antibodies against the central regionof Aβ and by naturally occurring p3 peptides, Aβ17-40 and A β17-42.
Neurochemical changes in welders revealed by proton magnetic resonance spectroscopy.
Cerebral amyloid angiopathy-linked β-amyloid mutations promote cerebral fibrin deposits via increased binding affinity for fibrinogen
- Steven A Cajamarca, E. Norris, L. van der Weerd, S. Strickland, H. J. Ahn
- Biology, MedicineProceedings of the National Academy of Sciences
- 9 June 2020
Significance We found an increased interaction between CAA-linked mutant Aβ and fibrin(ogen) that may not only result in severely altered fibrin structure and function but may also lead to vast…
Vascular endothelial growth factor associated dissimilar cerebrovascular phenotypes in two different mouse models of Alzheimer's Disease
Crystal Structure of Filamentous Aggregates of Human DJ-1 Formed in an Inorganic Phosphate-dependent Manner*
It is shown that inorganic phosphate, an important anion that exhibits elevated levels in patients with Parkinson disease, transforms DJ-1 into filamentous aggregates.
Interactions of &bgr;-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer's disease
- H. J. Ahn, Zu‐Lin Chen, D. Zamolodchikov, E. Norris, S. Strickland
- Biology, MedicineCurrent opinion in hematology
- 1 September 2017
Evidence is reviewed that the Alzheimer peptide interacts with the blood coagulation system and influences the pathophysiology of the disease, which can lead to increased clotting, abnormal clot formation, persistent fibrin deposition, and generation of proinflammatory molecules.