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Properties of Somatosensory Synaptic Integration in Cerebellar Granule Cells In Vivo
In decerebrated, nonanesthetized cats, we made intracellular whole-cell recordings and extracellular cell-attached recordings from granule cells in the cerebellar C3 zone. Spontaneous EPSPs hadExpand
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The cerebellar microcircuit as an adaptive filter: experimental and computational evidence
Initial investigations of the cerebellar microcircuit inspired the Marr–Albus theoretical framework of cerebellar function. We review recent developments in the experimental understanding ofExpand
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Synaptic Memories Upside Down: Bidirectional Plasticity at Cerebellar Parallel Fiber-Purkinje Cell Synapses
Information storage in neural circuits depends on activity-dependent alterations in synaptic weights, such as long-term potentiation (LTP) and long-term depression (LTD). Bidirectional synapticExpand
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Receptive Field Plasticity Profoundly Alters the Cutaneous Parallel Fiber Synaptic Input to Cerebellar Interneurons In Vivo
The cutaneous parallel fiber (PF) receptive fields of cerebellar stellate and basket cells in the cerebellar C3 zone in vivo are normally very small but can be dramatically enlarged by climbing fiberExpand
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In Vivo Analysis of Inhibitory Synaptic Inputs and Rebounds in Deep Cerebellar Nuclear Neurons
Neuronal function depends on the properties of the synaptic inputs the neuron receive and on its intrinsic responsive properties. However, the conditions for synaptic integration and activation ofExpand
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Reciprocal Bidirectional Plasticity of Parallel Fiber Receptive Fields in Cerebellar Purkinje Cells and Their Afferent Interneurons
The highly specific relationships between parallel fiber (PF) and climbing fiber (CF) receptive fields in Purkinje cells and interneurons suggest that normal PF receptive fields are established byExpand
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Consensus Paper: Towards a Systems-Level View of Cerebellar Function: the Interplay Between Cerebellum, Basal Ganglia, and Cortex
Despite increasing evidence suggesting the cerebellum works in concert with the cortex and basal ganglia, the nature of the reciprocal interactions between these three brain regions remains unclear.Expand
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Intrinsic Plasticity Complements Long-Term Potentiation in Parallel Fiber Input Gain Control in Cerebellar Purkinje Cells
Synaptic gain control and information storage in neural networks are mediated by alterations in synaptic transmission, such as in long-term potentiation (LTP). Here, we show using both in vitro andExpand
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Cerebellar molecular layer interneurons – computational properties and roles in learning
In recent years there has been an increased interest in the function of inhibitory interneurons. In the cerebellum this interest has been paired with successes in obtaining recordings from theseExpand
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Sensory transmission in cerebellar granule cells relies on similarly coded mossy fiber inputs
The computational principles underlying the processing of sensory-evoked synaptic inputs are understood only rudimentarily. A critical missing factor is knowledge of the activation patterns of theExpand
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