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Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha.
The transcription factor C/EBP alpha is required for granulopoiesis and frequently disrupted in human acute myeloid leukemia (AML). Here, we show disruption of C/EBP alpha blocks the transition from… Expand
Critical role for Gab2 in transformation by BCR/ABL.
The BCR/ABL oncogene causes chronic myelogenous leukemia (CML) in humans and a CML-like disease, as well as lymphoid leukemia, in mice. p210 BCR/ABL is an activated tyrosine kinase that… Expand
Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation.
The PU.1 transcription factor is a key regulator of hematopoietic development, but its role at each hematopoietic stage remains unclear. In particular, the expression of PU.1 in hematopoietic stem… Expand
Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis.
- Y. Arinobu, H. Iwasaki, +6 authors K. Akashi
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 13 December 2005
Basophils and mast cells, which are selectively endowed with the high-affinity IgE receptor and mediate a range of adaptive and innate immune responses, have an unknown developmental relationship.… Expand
Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1
Transcription factors are believed to have a dominant role in acute myeloid leukemia (AML). This idea is supported by analysis of gene-knockout mice, which uncovered crucial roles of several… Expand
Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages.
A hierarchical hematopoietic development with myeloid versus lymphoid bifurcation has been proposed downstream of the multipotent progenitor (MPP) stage, based on prospective isolation of progenitors… Expand
Obligate Role of Anti-Apoptotic MCL-1 in the Survival of Hematopoietic Stem Cells
Apoptosis is important in controlling hematopoietic stem cell (HSC) numbers. However, the specific BCL-2 family member(s) that regulate HSC homeostasis are not precisely defined. We tested myeloid… Expand
Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment.
We demonstrate here that "promiscuous" expression of myeloid or lymphoid genes precedes lineage commitment in hematopoiesis. Prospectively purified single common myeloid progenitors (CMPs) coexpress… Expand
Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis.
Hematopoietic stem cells (HSCs) maintain hematopoiesis by giving rise to all types of blood cells. Recent reports suggest that HSCs also possess the potential to generate nonhematopoietic tissues. To… Expand
Identification of eosinophil lineage–committed progenitors in the murine bone marrow
- H. Iwasaki, S. Mizuno, +6 authors K. Akashi
- Biology, Medicine
- The Journal of experimental medicine
- 20 June 2005
Eosinophil lineage–committed progenitors (EoPs) are phenotypically isolatable in the steady-state murine bone marrow. Purified granulocyte/monocyte progenitors (GMPs) gave rise to eosinophils as well… Expand