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Sickle cell anemia a molecular disease.
The erythrocytes of certain individuals possess the capacity to undergo reversible changes in shape in response to changes in the partial pressure of oxygen, and these cells change their forms from the normal biconcave disk to crescent, holly wreath, and other forms.
Phenanthrenequinone as an analytical reagent for arginine and other monosubstituted guanidines.
Hyposthenuria in sickle cell anemia: a reversible renal defect.
Solubilities of naturally occurring mixtures of human hemoglobin.
- H. Itano
- BiologyArchives of biochemistry and biophysics
- 1 November 1953
Ratio of sickle-cell anemia hemoglobin to normal hemoglobin in sicklemics.
THE ABNORMAL HUMAN HEMOGLOBINS
A new inherited abnormality of human hemoglobin.
A Third Abnormal Hemoglobin Associated with Hereditary Hemolytic Anemia.
- H. Itano
- MedicineProceedings of the National Academy of Sciences…
- 1 December 1951
The present report deals with the identification of still another form of human hemoglobin in five members of a family in which the genetic picture is not typical of sickle cell anemia, although two of the members have in the past been diagnosed as having sicklecell anemia.
Studies on the chemical modification of arginine. I. The reaction of 1,2-cyclohexanedione with arginine and arginyl residues of proteins.
- K. Toi, E. Bynum, E. Norris, H. Itano
- Chemistry, BiologyThe Journal of biological chemistry
- 10 March 1967
Peptide maps of tryptic digests of 1,2-cyclohexanedione-treated chains of hemoglobin showed blocking of hydrolysis at arginyl bonds with no change in positions oftryptic peptides not adjacent to arginy residues.
Induction of Haemolytic Anaemia by Substituted Phenylhydrazines
The parallelism between the formation of a ferrihaemoglobin compound and the induction of anaemia supports the hypothesis that destabilization of haemoglobin by the binding of a ligand derived from the aryl portion of an aRYlhydrazine is an essential step in aryLhydrazines‐induced haemolytic anaemia.