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Catalytic enantioselective addition to imines.
Chiral nitrogen-containing compounds are widely distributed in nature and include many biologically important molecules (Chart 1). In these compounds, the nitrogen-containing units are known to play… Expand
Catalytic Asymmetric Synthesis of Antimalarial Alkaloids Febrifugine and Isofebrifugine and Their Biological Activity.
- S. Kobayashi, Masaharu Ueno, R. Suzuki, H. Ishitani, H. Kim, Y. Wataya
- Chemistry, Medicine
- The Journal of organic chemistry
- 19 August 1999
Antimalarial alkaloids febrifugine (1) and isofebrifugine (2) were efficiently synthesized from simple achiral starting materials on the basis of the catalytic asymmetric synthesis. The first key… Expand
A novel inhibitor of ceramide trafficking from endoplasmic reticulum to the site of sphingomyelin synthesis.
- S. Yasuda, H. Kitagawa, +5 authors K. Hanada
- The Journal of Biological Chemistry
- 16 August 2013
Ceramide produced at the endoplasmic reticulum (ER) is transported to the lumen of the Golgi apparatus for conversion to sphingomyelin (SM). N-(3-Hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide… Expand
Catalytic asymmetric synthesis of febrifugine and isofebrifugine
Abstract Antimalarial alkaloids, febrifugine (1) and isofebrifugine (2), were synthesized from simple achiral starting materials using tin(II)-catalyzed catalytic asymmetric aldol reaction and… Expand
Asymmetric intramolecular [3 + 2] cycloaddition reactions of acylhydrazones/olefins using a chiral zirconium catalyst.
- S. Kobayashi, H. Shimizu, Y. Yamashita, H. Ishitani, J. Kobayashi
- Medicine, Chemistry
- Journal of the American Chemical Society
- 26 October 2002
Catalytic asymmetric intramolecular [3 + 2] cycloaddition of hydrazone/olefins has been attained. In the presence of a chiral zirconium catalyst prepared from zirconium alkoxide and a BINOL… Expand
Scandium trifluoromethanesulfonate (Sc(OTf)3). A novel reusable catalyst in the Diels-Alder reaction
Scandium trifluoromethanesulfonate (Sc(OTf)3) is found to be quite effective as a Lewis acid catalyst in the Diels-Alder reaction. The novel catalyst is available in both aqueous and organic media,… Expand
Synthesis of Biginelli dihydropyrimidinone derivatives with various substituents on aluminium-planted mesoporous silica catalyst.
- H. Murata, H. Ishitani, M. Iwamoto
- Chemistry, Medicine
- Organic & biomolecular chemistry
- 18 February 2010
Biginelli reactions were well catalyzed on mesoporous silica MCM-41 (M41) whose activity was much greater than that of amorphous silica. Octane was the most suitable among 6 kinds of solvents… Expand
Selective aldol reactions of acetals on mesoporous silica catalyst
Abstract Mukaiyama-aldol reactions of carbonyl compounds with silyl enol ethers were well catalyzed on siliceous mesoporous materials (MCM-41). The reactivity of acetals was much higher than that of… Expand
Probiotic culture of the rotifer Brachionus plicatilis
We adapted a probiotic culture system originally developed for domestic animals and fish for the intensive culture of rotifers. In this modification, a crude starter fluid was made by incubating a… Expand