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Catalytic enantioselective addition to imines.
Chiral nitrogen-containing compounds are widely distributed in nature and include many biologically important molecules (Chart 1). In these compounds, the nitrogen-containing units are known to play… Expand
A novel inhibitor of ceramide trafficking from endoplasmic reticulum to the site of sphingomyelin synthesis.
- S. Yasuda, H. Kitagawa, +5 authors K. Hanada
- The Journal of Biological Chemistry
- 16 August 2013
Ceramide produced at the endoplasmic reticulum (ER) is transported to the lumen of the Golgi apparatus for conversion to sphingomyelin (SM). N-(3-Hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide… Expand
Catalytic Asymmetric Synthesis of Antimalarial Alkaloids Febrifugine and Isofebrifugine and Their Biological Activity.
- S. Kobayashi, Masaharu Ueno, R. Suzuki, H. Ishitani, H. Kim, Y. Wataya
- Chemistry, Medicine
- The Journal of organic chemistry
- 19 August 1999
Antimalarial alkaloids febrifugine (1) and isofebrifugine (2) were efficiently synthesized from simple achiral starting materials on the basis of the catalytic asymmetric synthesis. The first key… Expand
Catalytic asymmetric synthesis of febrifugine and isofebrifugine
Abstract Antimalarial alkaloids, febrifugine (1) and isofebrifugine (2), were synthesized from simple achiral starting materials using tin(II)-catalyzed catalytic asymmetric aldol reaction and… Expand
Asymmetric intramolecular [3 + 2] cycloaddition reactions of acylhydrazones/olefins using a chiral zirconium catalyst.
- S. Kobayashi, H. Shimizu, Y. Yamashita, H. Ishitani, J. Kobayashi
- Medicine, Chemistry
- Journal of the American Chemical Society
- 26 October 2002
Catalytic asymmetric intramolecular [3 + 2] cycloaddition of hydrazone/olefins has been attained. In the presence of a chiral zirconium catalyst prepared from zirconium alkoxide and a BINOL… Expand
Scandium trifluoromethanesulfonate (Sc(OTf)3). A novel reusable catalyst in the Diels-Alder reaction
Scandium trifluoromethanesulfonate (Sc(OTf)3) is found to be quite effective as a Lewis acid catalyst in the Diels-Alder reaction. The novel catalyst is available in both aqueous and organic media,… Expand
Synthesis of Biginelli dihydropyrimidinone derivatives with various substituents on aluminium-planted mesoporous silica catalyst.
- H. Murata, H. Ishitani, M. Iwamoto
- Medicine, Chemistry
- Organic & biomolecular chemistry
- 18 February 2010
Biginelli reactions were well catalyzed on mesoporous silica MCM-41 (M41) whose activity was much greater than that of amorphous silica. Octane was the most suitable among 6 kinds of solvents… Expand
Selective aldol reactions of acetals on mesoporous silica catalyst
Abstract Mukaiyama-aldol reactions of carbonyl compounds with silyl enol ethers were well catalyzed on siliceous mesoporous materials (MCM-41). The reactivity of acetals was much higher than that of… Expand
Air-stable, storable, and highly selective chiral Lewis acid catalyst.
An air-stable, storable, and highly selective chiral Lewis acid catalyst for asymmetric Mannich-type reactions has been developed. The catalyst can be stored for more than three months in air at room… Expand
Probiotic culture of the rotifer Brachionus plicatilis
We adapted a probiotic culture system originally developed for domestic animals and fish for the intensive culture of rotifers. In this modification, a crude starter fluid was made by incubating a… Expand