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Calyculin A and okadaic acid: inhibitors of protein phosphatase activity.
The pattern of inhibition for the phosphatase in myosin B is similar to that of the type-1 enzyme, and the effects of both compounds on various phosphatases are screened. Expand
Calcium-independent activation of contractile apparatus in smooth muscle by calyculin-A.
From studies with intact smooth muscle it was demonstrated that, in the absence of external Ca++, CL-A can induce a contraction that was not accompanied by an increase in [Ca++]cyt, which is similar to those required to contract intact tissue. Expand
Changes in the cytoskeletal structure of cultured smooth muscle cells induced by calyculin-A.
The results suggest that CL-A may change the structure of focal contacts, resulting in the rounding up of the cell, and inducing a microtubule-severing activity, independent of the external Ca2+ concentration. Expand
Direct inhibition of chicken gizzard smooth muscle contractile apparatus by caffeine
Results indicate that caffeine inhibits smooth muscle contraction by a direct inhibition of MLC kinase and actinmyosin interaction, which may be mediated by cyclic AMP-dependent mechanism(s). Expand
Calcium-independent phosphorylation of smooth muscle myosin light chain by okadaic acid isolated from black sponge (Halichondria okadai).
Previously, we have shown that okadaic acid (OA), isolated from black sponge (Halichondria okadai) causes contraction even in the absence of Ca++ in the saponin-permealized taenia isolated fromExpand
Inhibitory effect of 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate (TMB-8) in vascular smooth muscle.
It is suggested that TMB-8 inhibits vascular smooth muscle contractility by inhibitingCa2+ influx, Ca2+ release and Ca2- sensitization of contractile elements. Expand