H. Irth

Publications175
h-index38
Citations4,686
Highly Influential Citations84
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Biosensor discovery of thyroxine transport disrupting chemicals.
Rapid dereplication of estrogenic compounds in pomegranate (Punica granatum) using on-line biochemical detection coupled to mass spectrometry.
Biosensor immunoassays for the detection of bisphenol A
Targeted LC–MS derivatization for aldehydes and carboxylic acids with a new derivatization agent 4-APEBA
AbstractBased on the template of a recently introduced derivatization reagent for aldehydes, 4-(2-(trimethylammonio)ethoxy)benzeneaminium dibromide (4-APC), a new derivatization agent was designed…
Trimethoprim: novel reactive intermediates and bioactivation pathways by cytochrome p450s.
TLDR
Preliminary results might implicate that genetic polymorphisms in P450 enzymes could play a role in the onset of TMP-related ADRs in humans.
High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural products.
Effect of the mobile phase composition on the separation and detection of intact proteins by reversed-phase liquid chromatography-electrospray mass spectrometry.
Biosensor recognition of thyroid-disrupting chemicals using transport proteins.
TLDR
The TPs-based biosensor assays were more sensitive, easier to perform, and faster to perform than the currently used methods such as radioligand binding assays and immunoprecipitation-HPLC.
Target Immobilization as a Strategy for NMR-Based Fragment Screening
TLDR
The authors find that HCS and TINS are the most sensitive to weak interactions, and SPR detection is most suited to ligands that bind with KD better than 1 mM, but the good correlation between SPR and potency in a bioassay makes this a good method for hit validation and characterization studies.
Reversed-phase liquid chromatography coupled on-line to receptor affinity detection based on the human estrogen receptor.
TLDR
On-line coupling of reversed-phase liquid chromatography to a biochemical detection system based on receptor-ligand interactions is described and the selectivity of the present method is demonstrated for the analysis of urine samples.
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