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A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions.
The data indicate that HPV 16 DNA prevails in malignant tumors, rendering an accidental contamination with papillomavirus DNA from adjacent papillomas rather unlikely, and suggests a dependence of HPV 16 replication on helper virus.
A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer.
DNA of a new papillomavirus type was cloned from a cervical carcinoma biopsy and the data reveal that the DNA might be integrated into the host cell genome, which is tentatively proposed to be HPV 18.
Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers.
The data support a genital origin of laryngeal papillomavirus infections and a possible role of this or related papillmavirus types in the induction of malignant genital tumors remains to be elucidated.
Analysis of oral papillomas, leukoplakias, and invasive carcinomas for human papillomavirus type related DNA.
Five papillomas, five leukoplakias, and six carcinomas were investigated for the presence of papillomavirus group-specific antigens and viral DNA and HPV type 11 and 16 DNA were used as probes in Southern blot hybridization at conditions of different stringency.
Vaccination trial with HPV16 L1E7 chimeric virus‐like particles in women suffering from high grade cervical intraepithelial neoplasia (CIN 2/3)
Evidence for safety and a nonsignificant trend for the clinical efficacy of the HPV16 L1E7 CVLP vaccine is demonstrated.
Screening for Cervical Cancer Precursors With p16/Ki-67 Dual-Stained Cytology: Results of the PALMS Study
The p16/Ki-67 dual-stained cytology combines superior sensitivity and noninferior specificity over Pap cytology for detecting CIN2+.
Human papillomavirus type 16 and early cervical neoplasia.
The presence of HPV 16 correlates with the presence of abnormal mitotic figures in flat warts of the cervix, and it is concluded that this type of flat wart is a precursor of invasive cancer of the cervical cervix.
Human papillomavirus type‐16‐related DNA in genital Bowen's disease and in bowenoid papulosis
32P‐labelled DNA of HPV 16 which has been isolated and molecularly cloned from a cervical carcinoma (Dürst et al., 1983) was used to screen the cellular DNAs obtained from 20 different biopsies of
Presence of human papillomavirus in genital tumors.
HPV types 16 and 18 have been identified in two different human cervical carcinomas and a similar distribution of the different papillomaviruses was observed when cell swabs taken from the cervix were tested by in situ hybridization.
Papillomavirus infection of the anogenital region: correlation between histology, clinical picture, and virus type. Proposal of a new nomenclature.
HPV-16, however, was found frequently in non-koilocytotic lesions exhibiting the features of severe epithelial atypia known in bowenoid papulosis, and the existence of PV structure antigens in these lesions could not be verified using the indirect immunoperoxidase--PAP-technique--in contrast to the koilocytosis lesions where clear evidence of the presence of HPV was proved.