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The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals…
The data suggest that the Ala12 variant is associated with a reduced risk for the development of diabetes in the general population, but that it may be also a risk factor for insulin deficiency and disease severity in individuals with type 2 diabetes.
Differential association of HLA with three subtypes of type 1 diabetes: fulminant, slowly progressive and acute-onset
- Y. Kawabata, H. Ikegami, Japan Diabetes Society on behalf of the Committee on Type 1 Diabetes
- Medicine, BiologyDiabetologia
- 8 October 2009
It is suggested that HLA associations with fulminant type 1 diabetes are qualitatively different from those with other subtypes of type 2 diabetes, whereas the HLA contribution to slowly progressive type 1 Diabetes is qualitatively similar to, but quantitativelyDifferent from, that in acute-onsettype 1 diabetes.
Low programmed cell death‐1 (PD‐1) expression in peripheral CD4+ T cells in Japanese patients with autoimmune type 1 diabetes
- R. Fujisawa, F. Haseda, T. Hanafusa
- Biology, MedicineClinical and experimental immunology
- 1 June 2015
The results indicate that lower PD‐1 expression in CD4+ T‐cells might contribute to the development of T1AD through T cell activation.
Diagnostic criteria for slowly progressive insulin-dependent (type 1) diabetes mellitus (SPIDDM) (2012): report by the Committee on Slowly Progressive Insulin-Dependent (Type 1) Diabetes Mellitus of…
- Shoichiro Tanaka, Masayuki Ohmori, Committee on Type 1 Diabetes
- Medicine, BiologyDiabetology International
Diagnostic criteria for slowly progressive insulin-dependent (Type 1) diabetes mellitus (SPIDDM) have been proposed and the presence of IA-2Ab, IAA, and ZnT8Ab were excluded, as it is still unclear whether insulinoma-associated antigen-2 autoantibodies (IA- 2Ab), insulin autoantibia (IAA), or zinc transporter 8 autoantIBodies (ZnT 8Ab) are essential markers for diagnosis.
Development of autoimmune diabetes in glutamic acid decarboxylase 65 (GAD65) knockout NOD mice
The data suggest that GAD65 is not a major regulatory target of beta-cell autoimmunity in NOD mice, suggesting that Type 1 diabetes mellitus of non-obese diabetic (NOD) mice is a T-cell-mediated autoimmune disease.
Direct evidence for susceptibility genes for type 2 diabetes on mouse chromosomes 11 and 14
These data provide direct evidence that Chr11 and Chr14 harbour major susceptibility genes for type 2 diabetes, and these two chromosomes interact to cause more severe hyperglycaemia and obesity, which was not observed with the presence of either single chromosome.
Variants of neurogenin 3 gene are not associated with Type II diabetes in Japanese subjects
Mutations and polymorphisms of ngn3 gene are not significantly associated with Type II (non-insulin-dependent) diabetes mellitus in the Japanese subjects.