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Sediment supply and the development of the coarse surface layer in gravel-bedded rivers
THE bed surface of most gravel rivers is considerably coarser than the sub-surface or the gravel load transported over it, a phenomenon affecting river dynamics, morphology and ecology. The coarseExpand
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Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells.
Bortezomib is a proteasome inhibitor with remarkable preclinical and clinical antitumor activity in multiple myeloma (MM) patients. The initial rationale for its use in MM was inhibition of nuclearExpand
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NMR Studies of Cyclodextrins and Cyclodextrin Complexes.
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Evolution of a sediment wave in an experimental channel
The routing of bed material through channels is poorly understood. We approach the problem by observing and modeling the fate of a low-amplitude sediment wave of poorly sorted sand that we introducedExpand
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Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma.
Multiple myeloma (MM) cells are characterized by high protein synthesis resulting in chronic endoplasmic reticulum (ER) stress, which is adaptively managed by the unfolded protein response.Expand
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Low-load resistance muscular training with moderate restriction of blood flow after anterior cruciate ligament reconstruction
We performed a prospective study to determine the effects of introducing low-load muscular training with moderate restriction of blood flow during the first 16 weeks after reconstruction of theExpand
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Repeated range expansion and glacial endurance of Potentilla glabra (Rosaceae) in the Qinghai-Tibetan plateau.
To date, little is still known about how alpine species occurring in the Qinghai-Tibetan Plateau (QTP) responded to past climatic oscillations. Here, by using variations of the chloroplast trnT-L, weExpand
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PI3K/p110{delta} is a novel therapeutic target in multiple myeloma.
In this study, we demonstrate expression and examined the biologic sequelae of PI3K/p110delta signaling in multiple myeloma (MM). Knockdown of p110delta by small interfering RNA caused significantExpand
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Effect of vitamin K2 on the recurrence of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is characterized by frequent recurrence, even after curative treatment. Vitamin K2, which has been reported to reduce HCC development, may be effective in preventingExpand
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SCL/TAL1 interrupting locus derepresses GLI1 from the negative control of suppressor-of-fused in pancreatic cancer cell.
As a physically binding protein of GLI1 transcription factor, Suppressor-of-Fused (SUFU) has been placed in the center of negative regulation of Hedgehog (Hh) signaling. SUFU tethers GLI1 inExpand
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