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Population Pharmacokinetics of Propofol: A Multicenter Study
Background: Target-controlled infusion is an increasingly common type of administration for propofol. This method requires accurate knowledge of pharmacokinetics, including the effects of age andExpand
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Incidence and predictors of difficult laryngoscopy in 11.219 pediatric anesthesia procedures
Objective:  Difficult laryngoscopy in pediatric patients undergoing anesthesia.
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Stereoselective pharmacokinetics of ketamine: R(−)‐Ketamine inhibits the elimination of S(+)‐ketamine
We investigated the pharmacokinetics of ketamine with special regard to enantiomer‐specific differences.
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Population pharmacokinetics of dexmedetomidine during long-term sedation in intensive care patients.
BACKGROUND Dexmedetomidine is a highly selective and potent α(2)-adrenoceptor agonist registered for sedation of patients in intensive care units. There is little information on factors possiblyExpand
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Population Pharmacokinetics of Propofol
Background: Target-controlled infusion is an increasingly common type of administration for propofol. This method requires accurate knowledge of pharmacokinetics, including the effects of age andExpand
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Different profiles of buprenorphine-induced analgesia and antihyperalgesia in a human pain model
&NA; Different mechanisms were proposed for opioid‐induced analgesia and antihyperalgesia, which might result in different pharmacodynamics. To address this issue, the time course of analgesic andExpand
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Pharmacokinetic-Pharmacodynamic Modeling of the New Steroid Hypnotic Eltanolone in Healthy Volunteers
Background In the last 4 y, several authors have reported largely satisfactory results using the new steroid intravenous anesthetic eltanolone (pregnanolone) to induce anesthesia. Until now, however,Expand
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Oxycodone clearance is markedly reduced with advancing age: a population pharmacokinetic study.
BACKGROUND Oxycodone is a µ-opioid receptor agonist, the global use of which has increased vigorously during the past decade. The pharmacokinetic data of oxycodone available for elderly are limited,Expand
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Comparative pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 and propofol emulsion.
BACKGROUND GPI 15715 is a new water-soluble prodrug that is hydrolyzed to release propofol. The objectives of this crossover study in volunteers were to investigate the pharmacokinetics andExpand
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Pharmacokinetics and clinical pharmacodynamics of the new propofol prodrug GPI 15715 in volunteers.
BACKGROUND GPI 15715 (AQUAVAN injection) is a new water-soluble prodrug which is hydrolyzed to release propofol. The objectives of this first study in humans were to investigate the safety,Expand
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