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- Publications
- Influence
Population Pharmacokinetics of Propofol: A Multicenter Study
- J. Schüttler, H. Ihmsen
- Medicine
- Anesthesiology
- 1 March 2000
Background: Target-controlled infusion is an increasingly common type of administration for propofol. This method requires accurate knowledge of pharmacokinetics, including the effects of age and… Expand
Incidence and predictors of difficult laryngoscopy in 11.219 pediatric anesthesia procedures
- S. Heinrich, T. Birkholz, H. Ihmsen, A. Irouschek, A. Ackermann, J. Schmidt
- Medicine
- Paediatric anaesthesia
- 1 August 2012
Objective: Difficult laryngoscopy in pediatric patients undergoing anesthesia.
Stereoselective pharmacokinetics of ketamine: R(−)‐Ketamine inhibits the elimination of S(+)‐ketamine
- H. Ihmsen, G. Geisslinger, J. Schüttler
- Chemistry, Medicine
- Clinical pharmacology and therapeutics
- 1 November 2001
We investigated the pharmacokinetics of ketamine with special regard to enantiomer‐specific differences.
Population pharmacokinetics of dexmedetomidine during long-term sedation in intensive care patients.
- T. Iirola, H. Ihmsen, +7 authors K. Olkkola
- Medicine
- British journal of anaesthesia
- 1 March 2012
BACKGROUND
Dexmedetomidine is a highly selective and potent α(2)-adrenoceptor agonist registered for sedation of patients in intensive care units. There is little information on factors possibly… Expand
Population Pharmacokinetics of Propofol
- H. Ihmsen
- Medicine
- 2000
Background: Target-controlled infusion is an increasingly common type of administration for propofol. This method requires accurate knowledge of pharmacokinetics, including the effects of age and… Expand
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Different profiles of buprenorphine-induced analgesia and antihyperalgesia in a human pain model
- W. Koppert, H. Ihmsen, Nicole Körber, A. Wehrfritz, J. Schüttler
- Medicine
- Pain
- 1 November 2005
&NA; Different mechanisms were proposed for opioid‐induced analgesia and antihyperalgesia, which might result in different pharmacodynamics. To address this issue, the time course of analgesic and… Expand
Pharmacokinetic-Pharmacodynamic Modeling of the New Steroid Hypnotic Eltanolone in Healthy Volunteers
- Werner J. Hering, H. Ihmsen, +4 authors J. Schuttler
- Medicine
- Anesthesiology
- 1 December 1996
Background In the last 4 y, several authors have reported largely satisfactory results using the new steroid intravenous anesthetic eltanolone (pregnanolone) to induce anesthesia. Until now, however,… Expand
Oxycodone clearance is markedly reduced with advancing age: a population pharmacokinetic study.
- T. Saari, H. Ihmsen, P. Neuvonen, K. Olkkola, H. Schwilden
- Medicine
- British journal of anaesthesia
- 1 March 2012
BACKGROUND
Oxycodone is a µ-opioid receptor agonist, the global use of which has increased vigorously during the past decade. The pharmacokinetic data of oxycodone available for elderly are limited,… Expand
Comparative pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 and propofol emulsion.
- J. Fechner, H. Ihmsen, +5 authors J. Schüttler
- Medicine
- Anesthesiology
- 1 September 2004
BACKGROUND
GPI 15715 is a new water-soluble prodrug that is hydrolyzed to release propofol. The objectives of this crossover study in volunteers were to investigate the pharmacokinetics and… Expand
Pharmacokinetics and clinical pharmacodynamics of the new propofol prodrug GPI 15715 in volunteers.
- J. Fechner, H. Ihmsen, +5 authors J. Schüttler
- Medicine
- Anesthesiology
- 1 August 2003
BACKGROUND
GPI 15715 (AQUAVAN injection) is a new water-soluble prodrug which is hydrolyzed to release propofol. The objectives of this first study in humans were to investigate the safety,… Expand