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A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors.
How the function of members of the TIF1 family in the control of transcription could be exerted at the level of the structure of the chromatin template is discussed.
A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus.
It is demonstrated that --1021C-->T is a major genetic marker for plasma-D beta H activity and provide new tools for investigation of the role of both D beta H and the DBH gene in human disease.
Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene
The identification of four independent mutations of the gene for GTP cyclohydrolase I in patients with HPD, as well as a marked decrease in the enzymes activity in mononuclear blood cells, confirms that the GTP cycling enzyme gene is a causative gene for HPD/DRD.
Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons
The results show that developmental pathways play key roles for the maintenance of terminally differentiated neurons and suggest that disrupted function of Nurr1 and other developmental transcription factors may contribute to neurodegenerative disease.
Changes in cytokines and neurotrophins in Parkinson's disease.
- T. Nagatsu, M. Mogi, H. Ichinose, A. Togari
- Biology, ChemistryJournal of neural transmission. Supplementum
Increased levels of proinflammatory cytokines, cytokine receptors and caspase activities, and reduced levels of neurotrophins in the nigrostriatal region in PD patients, and in MPTP- and 6OHDA-produced parkinsonian animals suggest increased immune reactivity and programmed cell death (apoptosis) of neuronal and/or glial cells.
Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis
The results suggest that Nr4a receptors have key roles in determining CD4+ T cell fates in the thymus and thus contribute to immune homeostasis.
Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity
- H. Kawasaki, H. Suemori, Y. Sasai
- BiologyProceedings of the National Academy of Sciences…
- 29 January 2002
It is reported here that SDIA induces efficient neural differentiation also in primate embryonic stem cells and provides an unlimited source of primate cells for the study of pathogenesis, drug development, and transplantation in degenerative diseases such as Parkinson's disease and retinitis pigmentosa.
Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders
It is proposed that an "immature DG" in adulthood might induce alterations in behavior and serve as a promising candidate endophenotype of schizophrenia and other human psychiatric disorders.
The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells
Nr4a2 has the ability to maintain T-cell homoeostasis by regulating induction, maintenance and suppressor functions of Tregs, and by repression of aberrant Th1 induction.