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TISSUE DISTRIBUTION AND METABOLISM OF NEWLY ABSORBED VITAMIN A IN THE RAT.
SUMMARY Chylomicrons containing newly absorbed labeled vitamin A were injected intravenously into normal intact rats, and the tissue distribution of radioactivity was observed for several days.Expand
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Corneal penetration behavior of beta-blocking agents II: Assessment of barrier contributions.
Rabbit corneas were excised and mounted in a chamber to determine the permeability characteristics of a group of beta-blocking agents. By measuring the permeability rate of each drug across intactExpand
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The intestinal absorption and metabolism of vitamin A and beta-carotene in man.
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Corneal penetration behavior of beta-blocking agents I: Physiochemical factors.
Rabbit corneas were excised and mounted in a chamber to determine the permeability characteristics of a group of beta-blocking agents which varied in octanol-water partitioning over a fourfoldExpand
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Biosynthesis of Vitamin A with Rat Intestinal Enzymes
Vitamin A is synthesized from β-carotene in cell-free homogenates of rat intestinal mucosa, the biosynthetic enzymatic activity being present in the soluble protein fraction of the homogenate. AlsoExpand
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Comparative cytotoxicity of non-steroidal anti-inflammatory drugs in primary cultures of rat hepatocytes.
The cytotoxicities of 12 non-steroidal anti-inflammatory drugs (NSAIDs) in primary monolayer cultures of rat hepatocytes were compared. Toxicity was determined by measuring the release of lactateExpand
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Mechanism of the biosynthesis of vitamin A from beta-carotene.
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Cytotoxicity of unsaturated metabolites of valproic acid and protection by vitamins C and E in glutathione-depleted rat hepatocytes.
Valproic acid (VPA) and the unsaturated metabolites, 2-ene VPA and (E)-2,(Z)-3'-diene VPA, demonstrated dose-dependent cytotoxicity in primary cultures of rat hepatocytes, as evaluated by lactateExpand
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Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis
A compound that reduces the prevalence of perinucleolar compartment in cancer cells inhibits metastasis in vivo. Blocking metastasis from the inside Metastasis, the spread of tumor cells that oftenExpand
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