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Stabilization of PML nuclear localization by conjugation and oligomerization of SUMO-3
The PML gene of acute promyelocytic leukemia (APL) encodes a cell-growth and tumor suppressor. PML localizes to discrete nuclear bodies (NBs) that are disrupted in APL cells, resulting from a… Expand
Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole
Individual variation in drug metabolism is a major cause of unpredictable side effects during therapy. Drug metabolism is controlled by a class of orphan nuclear receptors (NRs), which regulate… Expand
The consensus on indications, conditioning regimen, and donor selection of allogeneic hematopoietic cell transplantation for hematological diseases in China—recommendations from the Chinese Society…
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is widely used to treat malignant hematological neoplasms and non-malignant hematological disorders. Approximately, 5000 allo-HSCT… Expand
Rapid diagnosis and prognosis of de novo acute myeloid leukemia by serum metabonomic analysis.
- Yihuang Wang, Limin Zhang, +13 authors H. Tang
- Biology, Medicine
- Journal of proteome research
- 18 September 2013
Acute myeloid leukemia (AML) is a life-threatening hematological disease. Novel diagnostic and prognostic markers will be essential for new therapeutics and for significantly improving the disease… Expand
A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila
Disrupting mechanisms that control cell proliferation, cell size and apoptosis can cause changes in animal and tissue size and contribute to diseases such as cancer. The LATS family of… Expand
Phase 3 study of nilotinib vs imatinib in Chinese patients with newly diagnosed chronic myeloid leukemia in chronic phase: ENESTchina.
Treatment with a tyrosine kinase inhibitor (TKI) targeting BCR-ABL1 is currently the standard of care for patients with chronic myeloid leukemia (CML) in chronic phase (CML-CP). In this study, we… Expand
White-coat hypertension is a risk factor for cardiovascular diseases and total mortality
Background: Whether white-coat hypertension (WCH) is an innocent phenomenon is controversial. Method: In this study, we evaluated the association of WCH and the risk of cardiovascular diseases (CVDs)… Expand
HMGB1 induces apoptosis and EMT in association with increased autophagy following H/R injury in cardiomyocytes
- Fan Ouyang, H. Huang, +4 authors S. Zhou
- Biology, Medicine
- International journal of molecular medicine
- 29 January 2016
Hypoxia/reoxygenation (H/R) is a critical factor in the pathogenesis of tissue injury following myocardial infarction (MI) which can lead to tissue damage and pathological remodeling. Therefore, it… Expand
The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability
Loss or gain of whole chromosome, the form of chromosome instability commonly associated with cancers is thought to arise from aberrant chromosome segregation during cell division. Chromosome… Expand
A novel peptide ghrelin inhibits neural remodeling after myocardial infarction in rats.
- Ming-Jie Yuan, C. Huang, +4 authors T. Wang
- European journal of pharmacology
- 15 September 2009
Ghrelin is a newly discovered peptide as an endogenous ligand for the growth hormone secretagogue receptor, and has been demonstrated to exert beneficial effect in the cardiovascular system. In the… Expand