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A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms
Repressor activator protein 1 (RAP1) is the most highly conserved telomere protein. It is involved in protecting chromosome ends in fission yeast and promoting gene silencing in SaccharomycesExpand
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Domain Analysis Reveals That a Deubiquitinating Enzyme USP13 Performs Non-Activating Catalysis for Lys63-Linked Polyubiquitin
Deubiquitination is a reverse process of cellular ubiquitination important for many biological events. Ubiquitin (Ub)-specific protease 13 (USP13) is an ortholog of USP5 implicated in catalyzingExpand
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Structural Transformation of the Tandem Ubiquitin-Interacting Motifs in Ataxin-3 and Their Cooperative Interactions with Ubiquitin Chains
The ubiquitin-interacting motif (UIM) is a short peptide with dual function of binding ubiquitin (Ub) and promoting ubiquitination. We elucidated the structures and dynamics of the tandem UIMs ofExpand
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Interaction with synphilin‐1 promotes inclusion formation of α‐synuclein: mechanistic insights and pathological implication
α‐Synuclein (α‐Syn) is the major component of Lewy bodies (LBs) deposited in the brains of patients with Parkinson's disease. Synphilin‐1 (Sphl) is a novel α‐Syn‐interacting protein also present inExpand
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Solution structure of the Magnaporthe oryzae avirulence protein AvrPiz-t
Plants have evolved two major layers of defense mechanisms against invasion by diverse pathogens. When host membranes are exposed to pathogens, plants use extracellular surface receptors to identifyExpand
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Identification of Small Molecule Synthetic Inhibitors of DNA Polymerase β by NMR Chemical Shift Mapping*
DNA polymerase β (β-pol) plays a central role in repair of damaged DNA bases by base excision repair (BER) pathways. A predominant phenotype of β-pol null mouse fibroblasts is hypersensitivity to theExpand
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Structural Transformation of the Amyloidogenic Core Region of TDP-43 Protein Initiates Its Aggregation and Cytoplasmic Inclusion*
Background: The highly flexible C-terminal region of TDP-43 is implicated in disease pathology. Results: An amyloidogenic core was identified to be critical for TDP-43 aggregation. Conclusion:Expand
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Aggregation of the 35‐kDa fragment of TDP‐43 causes formation of cytoplasmic inclusions and alteration of RNA processing
TAR DNA binding protein of 43 kDa (TDP‐43) is a nuclear factor functioning in RNA processing. It is also a major deposited protein in amyotrophic lateral sclerosis (ALS) and frontotemporal lobarExpand
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Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation
TDP-43 is a DNA/RNA binding protein associated with TDP-43 proteinopathies. Many mutations have been identified in the flexible C-terminal region, which is implicated in the disease pathology. WeExpand
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Inhibition of alpha-synuclein fibrillization by dopamine analogs via reaction with the amino groups of alpha-synuclein. Implication for dopaminergic neurodegeneration.
Fibrillization of alpha-synuclein (alpha-Syn) is closely associated with the formation of Lewy bodies in neurons and dopamine (DA) is a potent inhibitor for the process, which is implicated in theExpand
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