Tumour necrosis factor-α causes an increase in blood-brain barrier permeability during sepsis
- N. Tsao, H. Hsu, Ching-ming Wu, Ching-Chuan Liu, H. Lei
- Biology, Medicine
- 1 September 2001
It was concluded that circulating TNF-α generated during sepsis induced the increase in blood-brain barrier permeability and could be inhibited by anti-TNF- α antibody.
Tumour necrosis factor-alpha causes an increase in blood-brain barrier permeability during sepsis.
Blood-brain barrier permeability during sepsis with Escherichia coli or Streptococcus pneumoniae was examined in a mouse model and measured by a circulating beta-galactosidase tracer and it was concluded that circulating TNF-alpha generated duringSepsis induced the increase in BBB permeability.
Significance of intraoperative peritoneal culture of fungus in perforated peptic ulcer
- Yen-Shen Shan, H. Hsu, Y. Hsieh, E. Sy, J.C.M. Lee, P. Lin
- MedicineBritish Journal of Surgery
- 1 October 2003
The aim of this study was to determine the significance of intraoperative peritoneal fluid culture of fungus and establish the indications for treatment.
Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrin
- Wei-Ching Chen, H. Hsu, M. Lai
- BiologyInternational Journal of Oncology
- 15 September 2016
Evidence is provided that CD90 mediates the antitumor formation by interacting with β3 integrin, which provides new insight that can potentially be applied in the development of therapeutic strategies in ovarian cancer.
Osteopontin-positive infiltrating tumor-associated macrophages in bulky ampullary cancer predict survival
Purpose: Tumor-associated macrophages (TAMs) promote cancer cell proliferation and distant metastases. Osteopontin (OPN) is overexpressed in several human cancer cells and in TAMs. Therefore, we set…
The Pylorus: Take It or Leave It? Systematic Review and Meta-Analysis of Pylorus-Preserving versus Standard Whipple Pancreaticoduodenectomy for Pancreatic or Periampullary Cancer
- P. Karanicolas, E. Davies, G. Guyatt
- MedicineAnnals of Surgical Oncology
- 8 March 2007
Moderate-quality evidence suggests PPPD is a faster procedure with less blood loss compared with SWPD, and large absolute differences in other key outcomes are unlikely; excluding relatively small differences will, however, require larger, methodologically stronger trials.
Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer
- Wei-Ching Chen, Yung-Sheng Chang, M. Lai
- Biology, ChemistryOncoTarget
- 22 October 2015
The signal axis of CD90-integrin-mTOR/AMPK-CD133 is critical for promoting liver carcinogenesis and molecules inhibiting the signal axis, including OSU-CG5 and other inhibitors, may serve as potential novel cancer therapeutic targets in liver cancer.
Increased expression of argininosuccinate synthetase protein predicts poor prognosis in human gastric cancer
- Y. Shan, H. Hsu, M. Lai, M. Yen, Yi-Pey Luo, Yi-Ling Chen
- Biology, MedicineOncology Report
- 20 October 2014
Ass expression in gastric cancer was associated with a poor prognosis and further study of mechanisms to silence the ASS gene or decrease the enzymatic activity of ASS protein has the potential to provide new treatments for patients with Gastric cancer.
Gene signatures and potential therapeutic targets of amino acid metabolism in estrogen receptor-positive breast cancer.
- Chih-Yang Wang, Chung-Chieh Chiao, M. Lai
- BiologyAmerican Journal of Cancer Research
It is demonstrated that amino acid metabolism genes play crucial roles in tumor development and may serve as prospective drug targets or biomarkers for ER+ breast cancer.
Impact of Etiologic Factors and APACHE II and POSSUM Scores in Management and Clinical Outcome of Acute Intestinal Ischemic Disorders after Surgical Treatment
Patients with MVT had a more favorable prognosis, whereas those with NOMI had the worst outlook, and the APACHE II and POSSUM scoring systems are useful in predicting the clinical outcome.