NMR studies on novel antitumor drug candidates, deoxoartemisinin and carboxypropyldeoxoartemisinin.
It is suggested that antitumor activity is not determined only with lipophilicity and that artemisinin derivatives have specific target proteins in each type of cancer.
Loss of oxidized and chlorinated bases in DNA treated with reactive oxygen species: implications for assessment of oxidative damage in vivo.
- M. Whiteman, H. Hong, A. Jenner, B. Halliwell
- Biology, ChemistryBiochemical and Biophysical Research…
- 30 August 2002
Bioinformatics Accelerates Drug Repositioning
- H. Hong
These two drugs are therefore good candidates for repositioning to treat lung cancer and inflammatory bowel disease that in need of better therapies, and the authors now have a way to mine available data for fast routes to new disease therapies.
Side effects of the anticancer drug hydroxycamptothecin on PC12 cell
- H. Hong
- Biology, Medicine
HCPT has side effects and toxic action on PC12 cell and the effect is maybe related with its role of inducing cell apoptosis which might be correlated with distribution of the cell cycle.
Synergistic antitumor effect of Andrographolide and cisplatin through ROS-mediated ER stress and STAT3 inhibition in colon cancer
- H. Hong, Wei-ke Cao, Quan Wang, Changbao Liu, Chongjie Huang
- Biology, ChemistryMedical Oncology
- 29 December 2021
It is found that Andrographolide synergizes with cisplatin in exerting anticancer activity in colon cancer cells, and ROS plays a pivotal role in mediating synergistic anticancer effects of AP and cis Platin.