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Cellular pharmacology of 2',3'-dideoxy-2',3'-didehydrothymidine, a nucleoside analog active against human immunodeficiency virus.
2',3'-Dideoxy-2',3'-didehydrothymidine (D4T) is a thymidine nucleoside analog which has potent anti-human immunodeficiency virus activity in vitro. We have studied its metabolism in cells to assist… Expand
Intracellular metabolism of the antiherpes agent (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine.
- H. Ho, K. Woods, J. Bronson, H. De Boeck, J. Martin, M. J. Hitchcock
- Biology, Medicine
- Molecular pharmacology
(S)-1-[3-Hydroxy-2-(phosphonylmethoxy)propyl]cytosine (HPMPC) is an antiviral phosphonate nucleotide analogue that displays activity against a range of herpesviruses. Anion exchange high performance… Expand
4-Thiazolidinones: novel inhibitors of the bacterial enzyme MurB.
- C. Andres, J. Bronson, +10 authors A. Walsh
- Medicine, Chemistry
- Bioorganic & medicinal chemistry letters
- 1 April 2000
4-Thiazolidinones were synthesized and evaluated for their ability to inhibit the bacterial enzyme MurB. Selected 4-thiazolidinones displayed activity against the enzyme in vitro. This activity,… Expand
Steady-state kinetic mechanism of Escherichia coli UDP-N-acetylenolpyruvylglucosamine reductase.
- A. Dhalla, J. Yanchunas, H. Ho, P. Falk, J. Villafranca, J. G. Robertson
- Chemistry, Medicine
- 25 April 1995
The Escherichia coli MurB gene encoding UDP-N-acetylenolpyruvylglucosamine reductase was expressed to a level of approximately 100 mg/L as a fusion construct with maltose binding protein. Rapid… Expand
Biochemical evidence for the formation of a covalent acyl-phosphate linkage between UDP-N-acetylmuramate and ATP in the Escherichia coli UDP-N-acetylmuramate:L-alanine ligase-catalyzed reaction.
In the peptidoglycan biosynthesis pathway in Escherichia coli, UDP-N-acetylmuramate:L-alanine ligase (MurC) catalyzes the formation of UDP-N-acetylmuramyl-L-alanine. A peptide bond is formed in this… Expand
Comparison of the D-glutamate-adding enzymes from selected gram-positive and gram-negative bacteria.
- A. Walsh, P. Falk, J. Thanassi, L. Discotto, M. Pucci, H. Ho
- Medicine, Biology
- Journal of bacteriology
- 1 September 1999
The biochemical properties of the D-glutamate-adding enzymes (MurD) from Escherichia coli, Haemophilus influenzae, Enterococcus faecalis, and Staphylococcus aureus were investigated to detect any… Expand
Staphylococcus haemolyticus contains two D-glutamic acid biosynthetic activities, a glutamate racemase and a D-amino acid transaminase.
Two D-glutamic acid biosynthetic activities, glutamate racemase and D-amino acid transaminase, have been described previously for bacteria. To date, no bacterial species has been reported to possess… Expand
Cellular metabolism and enzymatic phosphorylation of 9-(2-phosphonylmethoxyethyl) guanine (PMEG), a potent antiviral agent.
- H. Ho, K. Woods, S. Konrad, H. De Boeck, M. J. Hitchcock
- Biology, Medicine
- Advances in experimental medicine and biology
PMEG (9-(2-Phosphonylmethoxyethyl)guanine) is a potent, broad spectrum antiviral agent in the nucleoside phosphonate class (Figure 1). In vitro, PMEG is active against HSV-1, HSV-2, VZV, HCMV and… Expand
Cellular pharmacology of 2',3'-didehydro-2',3'-dideoxythymidine (D4T) in human peripheral blood mononuclear cells.
- Z. Zhu, H. Ho, M. J. Hitchcock, J. P. Sommadossi
- Chemistry, Medicine
- Biochemical pharmacology
- 1 May 1990
L'objet de l'etude est de determiner la production et la demi-vie intra-cellulaire du derive triphosphate de 2',3'-didehydro-2',3'-dideoxythymidine precedemment reconnu responsable de l'activite… Expand
UDP-N-acetylmuramyl-L-alanine functions as an activator in the regulation of the Escherichia coli glutamate racemase activity.
D-Glutamate is an essential component of the bacterial peptidoglycan. In Escherichia coli, the biosynthesis of D-glutamate is catalyzed by a glutamate racemase (encoded by the dga gene) and is… Expand