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Structural genomics projects in Japan.
Two major structural genomics projects exist in Japan and each has two major goals: to determine bacterial, mammalian, and plant protein structures by X-ray crystallography and NMR spectroscopy and to perform functional analyses with the target proteins. Expand
Newcastle disease virus evolution. II. Lack of gene recombination in generating virulent and avirulent strains.
The present study strongly supports the importance of the previously identified signals for gene expression and for the proteolytic activation of the gene product and identifies three distinct evolutionary lineages correlating with the virulence as expressed by mean death time (MDT) for chick embryo. Expand
Solution structure of the RWD domain of the mouse GCN2 protein
The solution structure of the mouse GCN2 RWD domain appears to be a novel structural domain for protein‐binding that plays specific roles in individual RWD‐containing proteins. Expand
Solution structure of a BolA‐like protein from Mus musculus
The structure of a mouse BolA‐like protein is determined, in which β1 and β2 are antiparallel, and β3 is parallel to β2, similar to the class II KH fold, except for the absence of the GXXG loop, which is well conserved in the KH fold. Expand
Solution structure of the antifreeze‐like domain of human sialic acid synthase
The structure of the C‐terminal antifreeze‐like (AFL) domain of human sialic acid synthase was determined by NMR spectroscopy and suggested that the class‐specific residues in the human and bacterial AFL domains are important for their substrate binding, while the class-specific residues of the fish antifREEze proteins are gathered on the ice‐binding surface. Expand
Solution Structure of the SEA Domain from the Murine Homologue of Ovarian Cancer Antigen CA125 (MUC16)*
The sequence alignment of the SEA domain family was refined on the basis of the three-dimensional structure, which allowed us to classify the SEA domains into several subfamilies, suggesting that each subfamily has a different function. Expand
Zinc suppresses Th17 development via inhibition of STAT3 activation.
It is shown that Zn suppresses T( h)17-mediated autoimmune diseases at lest in part by inhibiting the development of T(h)17 cells via attenuating STAT3 activation, which is a critical step for T(n)17 development. Expand
An α2-macroglobulin-like protein is the cue to gregarious settlement of the barnacle Balanus amphitrite
It is reported that a biological cue to gregarious settlement, the settlement-inducing protein complex (SIPC), of the major fouling barnacle Balanus amphitrite is a previously undescribed glycoprotein that may have evolved by duplication from an ancestral α2-macroglobulin gene. Expand
Ceratinamides A and B: New Antifouling Dibromotyrosine Derivatives from the Marine Sponge Pseudoceratina purpurea
Abstract Ceratinamides A and B ( 1 and 2 ), new bromotyrosine derivatives, have been isolated from the marine sponge Pseudoceratina purpurea , along with the known psammaplysins A ( 3 ) and E ( 4 ),Expand