H. Hirooka

Publications11
h-index5
Citations246
Highly Influential Citations4
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H+ gradient-dependent and carrier-mediated transport of cefixime, a new cephalosporin antibiotic, across brush-border membrane vesicles from rat small intestine.
The characteristics of the transport of cefixime, a new p.o. cephalosporin, antibiotic, were studied by using brush-border membrane vesicles from the rat small intestine. The initial rate of uptake… Expand
Saturable uptake of cefixime, a new oral cephalosporin without an α‐amino group, by the rat intestine
The mechanism of intestinal uptake of cefixime, a new oral cephalosporin antibiotic, has been examined using the everted jejunum of rats. The initial uptake rates were apparently pH‐dependent with… Expand
β-Lactam antibiotics and transport via the dipeptide carrier system across the intestinal brush-border membrane
Evidence for a carrier-mediated transport system in the small intestine available for FK089, a new cephalosporin antibiotic without an amino group.
Transport of a new cephalosporin developed for oral use, FK089, has been studied with the rat everted small intestine in vitro. Uptake was found to be pH-dependent with the maximum rate at an acidic… Expand
Characterization of the neurochemical effects of N-[2-(1-azabicyclo[3,3,0]octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946) as a cognition activator.
The neurochemical effects of SK-946, N-[2-(1-azabicyclo[3,3,0]octan-5-yl)ethyl]2-nitroaniline fumarate, were investigated in an attempt to elucidate cognition activating properties. In rat brain… Expand
INTESTINAL UPTAKE OF β-LACTAM ANTIBIOTICS WITHOUT AN α-AMINO GROUP AND ITS RELATIONSHIP TO DIPEPTIDE TRANSPORT
Effects of N-[2-(1-azabicyclo[3,3,0]octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946), a novel cognition activator, on learning and memory in rodent models.
We examined the effects of N-[2-(1-azabicyclo[3,3,0]octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946) on cognition in various rodent models. SK-946 slightly suppressed spontaneous motor activity, but… Expand
Beta-lactam antibiotics and transport via the dipeptide carrier system across the intestinal brush-border membrane.
TRANSPORT OF β-LACTAM ANTIBIOTICS VIA THE DIPEPTIDE CARRIER SYSTEM ACROSS INTESTINAL BRUSH-BORDER MEMBRANE
Population pharmacokinetics of faropenem in healthy human volunteers and patients
Faropenem (FRPM) is an oral penem antibacterial medicine with a high stability to beta-lactamase which has a broad antibacterial spectrum and a strong antibacterial activity to gram positive… Expand
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