H. Hirooka

Publications11
h-index5
Citations251
Highly Influential Citations4
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H+ gradient-dependent and carrier-mediated transport of cefixime, a new cephalosporin antibiotic, across brush-border membrane vesicles from rat small intestine.
TLDR
All the data obtained in this study demonstrate that cefixime transport across the brush-border membrane vesicles is carrier-mediated, independent of Na+ and dependent on a H+ gradient via the peptide transport systems.
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Saturable uptake of cefixime, a new oral cephalosporin without an α‐amino group, by the rat intestine
TLDR
This study provides the first evidence of saturable intestinal uptake of a cephem antibiotic without an α‐amino group in the side chain, suggesting transport through the dipeptide carrier system(s).
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β-Lactam antibiotics and transport via the dipeptide carrier system across the intestinal brush-border membrane
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Evidence for a carrier-mediated transport system in the small intestine available for FK089, a new cephalosporin antibiotic without an amino group.
TLDR
The results indicate that carrier-mediated transport is responsible for transport of cephem antibiotics without an alpha-amino group in the side chain at the 7-position of the cEPhem nucleus in the intestinal brush-border membrane.
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Characterization of the neurochemical effects of N-[2-(1-azabicyclo[3,3,0]octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946) as a cognition activator.
TLDR
Results suggest that SK-946 accelerates muscarinic neuronal transmission in the central nervous system.
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INTESTINAL UPTAKE OF β-LACTAM ANTIBIOTICS WITHOUT AN α-AMINO GROUP AND ITS RELATIONSHIP TO DIPEPTIDE TRANSPORT
Effects of N-[2-(1-azabicyclo[3,3,0]octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946), a novel cognition activator, on learning and memory in rodent models.
TLDR
An ability of SK-946 to enhance cognitive functions is suggested, as it ameliorated impaired learning and memory in rodents when administered before acquiring the training.
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Beta-lactam antibiotics and transport via the dipeptide carrier system across the intestinal brush-border membrane.
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Population pharmacokinetics of faropenem in healthy human volunteers and patients
TLDR
The prolongntion of the eliminntion half-lifp (t1/2) of faropenem was suggested in the patients with decreased kidney function as previously reported, and the population pharmacokinetic model of far Openem was made by taking these covariates into consideration.
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TRANSPORT OF β-LACTAM ANTIBIOTICS VIA THE DIPEPTIDE CARRIER SYSTEM ACROSS INTESTINAL BRUSH-BORDER MEMBRANE
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