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H+ gradient-dependent and carrier-mediated transport of cefixime, a new cephalosporin antibiotic, across brush-border membrane vesicles from rat small intestine.
TLDR
All the data obtained in this study demonstrate that cefixime transport across the brush-border membrane vesicles is carrier-mediated, independent of Na+ and dependent on a H+ gradient via the peptide transport systems.
Saturable uptake of cefixime, a new oral cephalosporin without an α‐amino group, by the rat intestine
TLDR
This study provides the first evidence of saturable intestinal uptake of a cephem antibiotic without an α‐amino group in the side chain, suggesting transport through the dipeptide carrier system(s).
Evidence for a carrier-mediated transport system in the small intestine available for FK089, a new cephalosporin antibiotic without an amino group.
TLDR
The results indicate that carrier-mediated transport is responsible for transport of cephem antibiotics without an alpha-amino group in the side chain at the 7-position of the cEPhem nucleus in the intestinal brush-border membrane.
Characterization of the neurochemical effects of N-[2-(1-azabicyclo[3,3,0]octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946) as a cognition activator.
TLDR
Results suggest that SK-946 accelerates muscarinic neuronal transmission in the central nervous system.
Effects of N-[2-(1-azabicyclo[3,3,0]octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946), a novel cognition activator, on learning and memory in rodent models.
TLDR
An ability of SK-946 to enhance cognitive functions is suggested, as it ameliorated impaired learning and memory in rodents when administered before acquiring the training.
Population pharmacokinetics of faropenem in healthy human volunteers and patients
TLDR
The prolongntion of the eliminntion half-lifp (t1/2) of faropenem was suggested in the patients with decreased kidney function as previously reported, and the population pharmacokinetic model of far Openem was made by taking these covariates into consideration.
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